Tytuł artykułu
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Abstrakty
From 2,4-dichloro-6-methylpyrimidine (1) via esters 2 and 3, (2-dimethylamino-6- methyl-4-pyrimidinylsulfanyl)acethydrazide (4) was synthesized. The latter under treatment either with carbon disulfide in the presence of a base or with potassium O-ethylxanthate in ethanol yielded 5-(2-dimethylamino-6-methyl-4-pyrimidinylsulfanylmethyl)-1,3,4- oxadiazole-2-thione (5). Alkylation of 5 afforded S-alkyl derivatives 6a,b, whereas aminomethylation, acylation or cyanoethylation gave N(3)-substituted derivatives 7-9. Compounds were tested for their anti-inflammatory activity.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
Strony
557--563
Opis fizyczny
Bibliogr. 14 poz., rys.
Twórcy
autor
- Faculty of Chemistry, Vilnius University, Naugarduko 24, LT-2006, Vilnius, Lithuania
autor
- Faculty of Chemistry, Vilnius University, Naugarduko 24, LT-2006, Vilnius, Lithuania
autor
- FacuIty of Medicine, Vilnius University, M.K. Ciurlionio 21, LT-2009, Vilnius, Lithuania
autor
- Faculty of Chemistry, Vilnius University, Naugarduko 24, LT-2006, Vilnius, Lithuania
Bibliografia
- 1. Pancechowska-Ksepko D., Foks H., Landowska E., Janowiec H. and Zwolska-Kwiek Z., Acta Pol. Pharm., 43, 116(1986).
- 2. Krasovsky A.N., Bulgakov A.K., Andrushko A.P., Krasovsky I.A., Djachenko A.M., Bokun A.A., Kravchenko N.A. and Demchenko A.M., Khim.-Pharm. Zh., 34, 13 (2000).
- 3. Yamamoto S., Jap. Pat. 05124948; C.A., 119, 146370 (1993).
- 4. Bochelli D.H., Connor D.T., Kostlan C.R., Kramer J.B., Mullican M.D. and Sircar J.Ch., EP Pat 449211; C.A., 116, 6570 (1992).
- 5. Bellioti T.R., Connor D.T. and Kostlan C.R., WO Pat. 9213844; C.A., 118, 6990 (1993).
- 6. Song I., Connor D.T., Sercel A.D., Soreson R.J., Doubledoy R., Unangst P.C., Roth B.D., Beylin V.G., Gilbersten R.B., Chan K., Schrier D., Guglieta A., Bomemeier D. and Dyer R.D., J. Med. Chem. 42 1161 (1999).
- 7. Eckhardt W., Beriger E. and Zondler H., EP Pat. 371925; C.A., 113, 191385 (1990).
- 8. Bettarini F., Capuzzi L„ La Porta P., Massimini S. and Caprioli V., EP Pat. 533276; C.A., 119, 49400 (1993).
- 9. Mekuäkiene G., Vainilaviäius P., Hetzheim A. and Sematoviö R., Khim. Geterotsikl. Soedin., 5, 700 (1993).
- 10. Matsukawa T. and Ohta B., J. Pharm. Soc. Jap., 70, 134 (1950).
- 11. Vainilavicius P. J., Burbuliene M.-M. V., Rocka V.-S.M. and Lauciuviene N.-D.I., Khim. - Pharm Zh. 16 931 (1982).
- 12. Winter C.A., Risley E.A. and Nuss G.W., Proc. Soc. Exp. Biol. Med., 3, 544 (1962).
- 13. Marek J., Pharmazie, 36, 46 (1981).
- 14. Litchfield J.T. and Wilkoxon F., J. Pharmacol. Exp. Ther., 96, 99 (1949).
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BUJ1-0020-0059