New Analogues of Cucurbita maxima Trypsin Inhibitor III (CMTI-III) Substituted with D-Arg or D-Lys in Position 5 (P1)

• Autorzy: Frąszczak P. , Rolka K. , Kupryszewski G.
• Języki publikacji: EN

Abstrakty

EN

Two new analogues of trypsin inhibitor CMTI-III substituted with D-Arg or D-Lys in position 5 (P1) were synthesized by the solid-phase method. The first analogue ([D-Arg5] CMTI-III) displayed association equilibrium constants (Ka) with bovine -trypsin by about three orders of magnitude lower than did wild CMTI-III. The second analogue ([D-Lys5] CMTI-III) displayed Ka by about four orders of magnitude lower than [Lys5] CMTI-III. The configuration of basic amino acid residue (Arg or Lys) in the reactive site (position P1) of CMTI-III and its analogues played an important role for the stabilization of the inhibitors active structure.

Słowa kluczowe

EN

peptid tryspin inhibitors; solid-phase peptide synthesis

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2002
• Tom: Vol. 76 / nr 4
• Strony: 519--523
• Opis fizyczny: Bibliogr. 13 poz., rys.

Twórcy

autor

Frąszczak P.

• Faculty of Chemistry, University of Gdańsk, 80-952 Gdańsk, Sobieskiego 18, Poland

autor

Rolka K.

• Faculty of Chemistry, University of Gdańsk, 80-952 Gdańsk, Sobieskiego 18, Poland

autor

Kupryszewski G.

• Faculty of Chemistry, University of Gdańsk, 80-952 Gdańsk, Sobieskiego 18, Poland

Bibliografia

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