Synthesis and Cytotoxic Properties of N-Boc-phenylisoserinates of Sesquiterpenoic Alcohols from Mushrooms of Lactarius Genus, as Analogues of Taxotere

• Autorzy: Sarosiek A. , Masnyk M. , Gumułka M. , Daniewski W. M. , Kobus M. , Krawczyk E. , Łuczak M.
• Języki publikacji: EN

Abstrakty

EN

Sesquiterpenoic analogues of TaxotereŽ i.e., N-BOC-phenylisoserinates of sesquiterpenoic alcohols, isolated from mushrooms of Lactarius genus, were synthesized. Cytotoxicity of compounds, thus obtained, was evaluated using Vero cells.

Słowa kluczowe

EN

(2'R,3"S)-N-BOC-phenylisoserinates; cytotoxicity

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2002
• Tom: Vol. 76 / nr 1
• Strony: 73--82
• Opis fizyczny: Bibliogr. 10 poz., rys.

Twórcy

autor

Sarosiek A.

• Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44, 01-224 Warsaw, Poland

autor

Masnyk M.

• Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44, 01-224 Warsaw, Poland

autor

Gumułka M.

• Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44, 01-224 Warsaw, Poland

autor

Daniewski W. M.

• Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44, 01-224 Warsaw, Poland

autor

Kobus M.

• Department of Medical Microbiology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, Poland

autor

Krawczyk E.

• Department of Medical Microbiology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, Poland

autor

Łuczak M.

• Department of Medical Microbiology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, Poland

Bibliografia

• 1.Daniewski W.M., Gumułka M., Ptaszyńska K., Słubicki R, Błoszyk E., Drożdż B., Strombeig S., Norin T. and Hołub M., Eur.J. Entomol 90,65 (1993).
• 2.Daniewski W.M., Gumułka M., Przesmycka D., Ptaszyńska K., Błoszyk E., Drożdż B., Phytochem., 38, 1161 (1995).
• 3.Kobus M., Łuczak M., Krawczyk E., Wajs K., Kopczacki P. and Daniewski W.M., Proc. 12th Mediterranean Congress of Chemotherapy, Marakesh, Moroco, 271 (2000).
• 4.Kobus M., Przybylski M., Łuczak M., Krawczyk E., Kopczacki P. and Daniewski W.M., Proc. 12th Mediterranean Congress ofChemotherapy, Marakesh, Moroco, 141 (2000).
• 5.Daniewski W.M.,Gumulka M., Kopczacki P. and Masnyk M.,Polish J. Chem.,75, 1287 1296 (2001).
• 6.The Chemistiy and Phaimacology of Taxol and Its Derivatives. Editor Farina V., Elseyier Science B.V. (1995).
• 7.Daniewski W.M. and Vidari G., Próg. Chem. Org. Nat. Prod., 77,69-171 (1999).
• 8.Wang Z., Kolb H.C.and Sharpless K.B., Org. Chem., 59,5104 (1994).
• 9. Mosmann T., J. Immunol. Methods, 65 (1-2), 55 (1983).
• 10. Denizot F. and Lang R., J. Immunol Methods, 89 (2), 271 (1986).