On the Peptides Related to Nucleotide Sequences of Archeal tRNAs

• Autorzy: Siemion I.
• Języki publikacji: EN

Abstrakty

EN

It is shown that the nucleotide sequences of archeal tRNAs correspond to peptide sequences, some of which resemble very much the contemporary regulatory peptides. In particular, the nucleotide sequence of archeal A0980 tRNAAla corresponds to a putative polypeptide, which is homologous to thymopoietin, a peptide hormone produced in thymus and endowed with immunomodulatory activity. The 23 amino acid long synthetic peptide corresponding to A0980 interacts strongly with TAR RNA fragment of HIV mRNAs as well as binds specifically to tRNAPhe, whereas tRNALeu and tRNAMet are deprived of such ability.

Słowa kluczowe

EN

archeal tRNAs; RNA world; peptides related to tRNAs; thymopoietin homology

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2001
• Tom: Vol. 75, nr 10
• Strony: 1449--1456

Twórcy

autor

Siemion I.

• Faculty of Chemistry, Wrocław University, 50-383 Wrocław, Poland