Pro-Pro Amide Bond Configuration and the Immunosuppressive Activity of Cyclolinopeptide A

• Autorzy: Krajewski K.
• Języki publikacji: EN

Abstrakty

EN

The comparison of conformational preferences of cyclolinopeptide A (CLA) analogues containing the twisted cis-amide bond mimetics, based on CD, molecular modeling, and their immunosuppressive activity was performed. The results suggest that there exists a twisted cis-amide bond between two proline residues in the biologically active conformation of CLA.

Słowa kluczowe

EN

cis-amide bond mimetics; cis/trans isomerization; cyclophilin A; cyclolinopeptide A analogues

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2001
• Tom: Vol. 75, nr 10
• Strony: 1441--1448

Twórcy

autor

Krajewski K.

• Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland