Peptidyl Diazomethylketones as Cysteine Protease Inhibitors Structurally Based Upon the Inhibitory Centers of Cystatins

• Autorzy: Kasprzykowski F. , Kasprzykowska R. , Kania R. , Plucińska K. , Grubb A. , Abrahamson M. , Schalėn C.
• Języki publikacji: EN

Abstrakty

EN

Six new putative cysteine protease inhibitors based upon sequences of the N-terminal binding fragments of rat cystatin A, bovine cystatin C and human cystatins D and S were synthesized. Inhibitory activities of these compounds against papain and bovine cathepsin B were tested. Additionally, agar well diffusion test of their antibacterial activity against Streptococcus pyogenes was performed.

Słowa kluczowe

EN

cysteine proteases; cystatins; peptidyl diazomethanes

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2001
• Tom: Vol. 75, nr 6
• Strony: 831--837
• Opis fizyczny: Bibliogr. 22 poz., rys.

Twórcy

autor

Kasprzykowski F.

• Faculty of Chemistry, University of Gdansk, 80-952 Gdansk, Poland

autor

Kasprzykowska R.

• Faculty of Chemistry, University of Gdansk, 80-952 Gdansk, Poland

autor

Kania R.

• Faculty of Chemistry, University of Gdansk, 80-952 Gdansk, Poland

autor

Plucińska K.

• Faculty of Chemistry, University of Gdansk, 80-952 Gdansk, Poland

autor

Grubb A.

• Department of Clinical Chemistry, University Hospital, S-221S5 Lund, Sweden

autor

Abrahamson M.

• Department of Clinical Chemistry, University Hospital, S-221S5 Lund, Sweden

autor

Schalėn C.

• Department of Infectious Diseases and Medical Microbiology, University Hospital, S-22185 Lund, Sweden

Bibliografia

• 1. Bond J.S. and Butler E., Ann. Rev. Biochem., 56, 333 (1987).
• 2. Shaw E., Adv. Enzymol., 63, 271 (1990).
• 3. Barret A,J. and Rawlings N.D., Biochem. Soc. Trans., 19, 707 (1991).
• 4. Kamphuis I.G., Drenth J. and Baker E.N., J. Mol. Biol., 182, 317 (1985).
• 5. Musil D,, Zucic D,, Turk D., Engh R.E,, Mayr I., Iluber R., Popovic T., Turk V., Towatari T., Katunuma N. and Bode W., EMBO J., 10,2321 (1991).
• 6. Katunuma N. and Kominami E., Rev. Physiol. Biochem. Pharmacol., 108, 1 (1987).
• 7. van Noorden C.J., Smith R.E. and Rasnick D., J. Rheumatol., 15, 1525 (1988).
• 8. Page A.E., Warburton M.J., Chambers T.J., Pringle J.A.S. and Hayman A.R., Biochim. Biophvs. Acta., 1116, 57(1992).
• 9. Délaissé J.M., Pascale L. and Vaes G., Biochem. J., 279, 167 (1991).
• 10. Lah T.T., Kokalj-Kunovar M., Strukelj B., Pungercar J., Barlic-Maganja D., Drobnic-Kosorok M., Kastelic L., Babnik J., Golouh R. and Turk V., Int. J. Cancer, SO, 36 (1992).
• 11. Gabrijelcic D., Svetic B., Spaic D., Skrk., J., Budihna M., Dolenc L, Popovic T., Cotic V. and Turk V., Eur. J. Clin. Chem. Clin. Biochem,, 30, 69 (1992).
• 12. Bauet A.J., Fritz H., Grubb A., Isemura S., Järvinen M., Katunuma N., Malcheidt W., Müller-Esterl W., Sasaki M. and Turk V., Biochem. J., 236, 312 (1986).
• 13. Bode W., Engh R., Musit D., Thiele U., Huber R., Karshnikov A., Brzin J., Kos J., and Turk, EMBO J., 7, 2593(1988).
• 14. Stubbs M.T., Laber B., Bode W., Huber R., Jerala R,, Lenarcic B. and Turk V., EMBO J., 9, 1939 (1990).
• 15. Grubb A., Abrahamson M., Olafsson I., Trojnar J., Kasprzykowska R., Kasprzykowski F. and Grzonka Z., Biol. Chem. Hoppe-Seyler; 371, Suppl, 137 (1990).
• 16. Hall A., Abrahamson M., Grubb A., Trojnar J., Kania P., Kasprzykowska R. and Kasprzykowski F., J. Enzyme Inhibition, 6, 113 (1992).
• 17. Tarnowska M., Ołdziej S., Liwo A., Kasprzykowski F. and Grzonka Z., Eur. Biophys. J., 21, 217(1992).
• 18 .Björk L., Akesson P., Bohus M., Trojnar J., Abrahamson M., Olafsson I. and Grubb A., Nature, 337, 385 (1987).
• 19. Crawford C., Mason RW., Wikstrom P. and Shaw E„ Biochem. J., 253, 751 (1988).
• 20. Rawlings N.D. and Barret A.J., Computer Appl. Biosci, 6, 118 (1990).
• 21. Hall A., Ekiel I., Manson R.W., Kasprzykowski F., Grubb A. and Abrahamson M., Biochem., 37, 4071
• 22. Kasprzykowski F., Schalen C., Kasprzykowska R., Jastrzębska B. and Grubb A., APMIS, 108. 473 (2000).