Bisbenzisoselenazol-3(2H)-ones, a New Group of Ebselen Analogues

• Autorzy: Osajda M. , Kloc K. , Młochowski J. , Piasecki E. , Rybka K.
• Języki publikacji: EN

Abstrakty

EN

The title compounds with benzisoselenazolone moieties connected by spacers such as phenylene, bisphenylene, alkylene, oxaalkylene, azaalkylene and dithiaalkylene groups have been obtained in the reaction of 2-(chloroseleno)benzoyl chloride with compounds having two primary amine groups, while the secondary amines gave products of their selenenylation and/or acylation. Bisbenzisoselenazol-3(2H)-ones were found, in the antiviral assay in vitro, to be inhibitors of cytopathic activity of RNA and DNA viruses: EMCV, HSV-1 and VSV.

Słowa kluczowe

EN

bisbenzisoselenazol-3(2H)-ones; 2-(chloroseleno)benzoyl chloride; diselenides; ebselen analogues; virucides

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2001
• Tom: Vol. 75, nr 6
• Strony: 823--830
• Opis fizyczny: Bibliogr. 11 poz., rys.

Twórcy

autor

Osajda M.

• Institute of Organic Chemistry, Biochemistry and Biotechnology, Wrocław University of Technology, Wyb. Wyspiańskigo 27, 50-375 Wrocław, Poland

autor

Kloc K.

• Institute of Organic Chemistry, Biochemistry and Biotechnology, Wrocław University of Technology, Wyb. Wyspiańskigo 27, 50-375 Wrocław, Poland

autor

Młochowski J.

• Institute of Organic Chemistry, Biochemistry and Biotechnology, Wrocław University of Technology, Wyb. Wyspiańskigo 27, 50-375 Wrocław, Poland

autor

Piasecki E.

• Laboratory of Virology, łnstitute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wrocław, Poland

autor

Rybka K.

• Laboratory of Virology, łnstitute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wrocław, Poland

Bibliografia

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