Cine-Substitution of Nitro Group in 1-Aryl-2-methyl-4-nitroimidazoles by Thiols; X-ray Diffraction Proof for the Product Structure

• Autorzy: Suwiński J. , Świerczek K. , Wagner P. , Kubicki M. , Borowiak T.
• Języki publikacji: EN

Abstrakty

EN

1-Aryl-2-methyl-4-nitroimidazoles react with 2-amino- or with 2-hydroxyethanethiols to give products of cine-substitution of the nitro group. 5-(2_-Hydroxyethylthio)-2- methyl-1-phenylimidazole has been isolated as a free base, other products in the form of dipicrates. A structure of 5-(2_-aminoethylthio)-2-methyl-1-phenylimidazole dipicrate was proved by X-ray diffraction.

Słowa kluczowe

EN

1-aryl-4-nitroimidazoles; thiols; cine substitution; X-ray

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Polish Journal of Chemistry
• Rocznik: 2001
• Tom: Vol. 75, nr 5
• Strony: 639--647
• Opis fizyczny: Bibliogr. 16 poz., rys.

Twórcy

autor

Suwiński J.

• Institute of Organic Chemistry and Technology, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland

autor

Świerczek K.

• Institute of Organic Chemistry and Technology, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland

autor

Wagner P.

• Institute of Organic Chemistry and Technology, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland

autor

Kubicki M.

• Adam Mickiewicz University, Faculty of Chemistry Grunwaldzka 6, 60-780 Poznań, Poland

autor

Borowiak T.

• Adam Mickiewicz University, Faculty of Chemistry Grunwaldzka 6, 60-780 Poznań, Poland

Bibliografia

• 1. Ostrowski S., Polish J. Chem., 68,2237 (1994).
• 2. Suwiński J. and Swierczek K., Khim. Geterotsykl. Soed, 1214(1996).
• 3. Suwiński J., Pawlus W., Salwińska E. and Swierczek K., Heterocycles, 37, 2237 (1994).
• 4. Smithen C. E. and Hardy C.R, in Advanced Topics on Radiosensitizers of Hypoxic Cells, NY, 1982, p. 1.
• 5. Voogd CF., Mutation Research, 86, 243 (1981).
• 6. Goldman P, and Wuest J.D., J. Ant. Chem. Soc., 103, 6224 (1981).
• 7. Suwiński J. and Świerczek K.,Tetrahedron Reports, a review (in press),
• 8. Girard M., Clairmont F., Maneckje A., Mousseau N., Dawson B. and Whitehouse L., Can J.Chem 71 1349(1993).
• 9. Boyer J.H.. Nitroimidazoles, VCH Publishers Inc., Deerfield Beach, Florida 1986.
• 10. Wardman P. and Clarke E.D., J. Chem. Soc., Faraday Trans. I, 72, 1377 (1976).
• 11. Cosar C., Crisan C., Horclois R., Jacob R.M., Robert J., Tchelttcheff S. and Vaupré R Arzem Forsch 16,23(1966).
• 12. Salwińska E. and Suwiński J., Polish J. Chem., 64, 813 (1990).
• 13. KUMA (1991). Kuma KM-4 Users Guide. Version 5.0. Kuma Diffraction, Wroclaw, Poland
• 14. Sheldrick G.M., Acta Ciyst. A, 46, 467 (1990).
• 15. Sheldnck G.M., SHBLXL97, Program for the Refinement of Crystal Structures, University of Göttingen, Germany (1997).
• 16. Siemens, Stereochemical Workstation, Siemens Analytical X-ray Instruments Inc., Madison Wisconsin, USA (1989).