A Model for estimating cell kinetic parameters of experimental tumours studied by BrdUrd labelling and flow cytometry

• Autorzy: Bertuzzi A. , Gandolfi A.
• Języki publikacji: EN

Abstrakty

EN

A mathematical model that describes the time evolution of the DNA-BrdUrd distribution, as measured in experimental tumours after labelling with BrdUrd, is proposed in this paper. Cell-to-cell heterogeneity within the tumour of the rate of progression across cell cycle phases is taken into account, and a strict correlation between the durations of S and G2M phases is assumed. The model relates observable quantities to the parameters that characterize the cell population kinetics (such as the potential doubling time, T pot), and appears thus to be suitable for parameter estimation. Simulations that illustrate the dependence of model response on the kinetic parameters are presented.

• Wydawca: Polish Academy of Sciences, Committee of Automatic Control and Robotics
• Czasopismo: Archives of Control Sciences
• Rocznik: 1999
• Tom: Vol. 9, no. 1/2
• Strony: 41--56
• Opis fizyczny: Bibliogr. poz 12

Twórcy

autor

Bertuzzi A.

autor

Gandolfi A.

• Instituto di Analisi ed Informatica del CNR Viale Manzoni, Italy