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A mathematical model that describes the time evolution of the DNA-BrdUrd distribution, as measured in experimental tumours after labelling with BrdUrd, is proposed in this paper. Cell-to-cell heterogeneity within the tumour of the rate of progression across cell cycle phases is taken into account, and a strict correlation between the durations of S and G2M phases is assumed. The model relates observable quantities to the parameters that characterize the cell population kinetics (such as the potential doubling time, T pot), and appears thus to be suitable for parameter estimation. Simulations that illustrate the dependence of model response on the kinetic parameters are presented.
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Tom
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41--56
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Bibliogr. poz 12
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- Instituto di Analisi ed Informatica del CNR Viale Manzoni, Italy
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Bibliografia
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bwmeta1.element.baztech-article-BSW9-0001-0034