Model based monitoring of hypothermic patients

• Autorzy: Schwarz M. , Heilmann C. , Krueger M. W. , Kiencke U.
• Języki publikacji: EN

Abstrakty

EN

In open heart surgery the patient is connected to a heart-lung machine which pumps and oxygenizes the blood. The body core temperature is reduced by cooling the blood in a heat exchanger to reduce oxygen consumption of the tissues and so protect organs from hypoxia. Monitoring of vital parameters is crucial for safety of the patient. However, only little information is available from direct measurement. Models of haemodynamics and heat exchange in the human body are presented in this paper which provide the perfusionist with detailed data on blood flow and temperature in regions of the body which cannot be accessed by measurement devices. Simulation is performed on a real-time hardware platform which receives measured signals from the heart-lung machine via a serial interface.

Słowa kluczowe

EN

biomedical engineering; human modelling; real-time application

• Wydawca: Komitet Metrologii i Aparatury Naukowej PAN
• Czasopismo: Metrology and Measurement Systems
• Rocznik: 2009
• Tom: Vol. 16, nr 3
• Strony: 443--455
• Opis fizyczny: Bibliogr. 30, rys., wykr.

Twórcy

autor

Schwarz M.

autor

Heilmann C.

autor

Krueger M. W.

autor

Kiencke U.

• Universität Karlsruhe (TH), Institut für Industrielle Informationstechnik, Hertzstr. 16, 76187 Karlsruhe, Germany,

Bibliografia

• [1] R.J. Tschaut: Extracorporeal circulation in theory and practice. Pabst Science Publishers, 1999. (in German)
• [2] A.P. Avolio: “Multi-branched model of the human arterial system”. Med Biol Eng Comput, vol. 18, 1980, pp. 709-718.
• [3] H.H. Pennes: “Analysis of tissue and arterial blood temperatures in the resting human forearm”. J. Appl. Physiol., vol. 1, no. 2, 1948, pp. 93-102.
• [4] J. Alastruey, K.H. Parker, J. Peiró, S.M. Byrd, S.J. Sherwin: “Modelling the circle of Willis to assess the effects of anatomical variations and occlusions on cerebral flows”. J. Biomech., vol. 40, no. 8, 2007, pp. 1794 -1805.
• [5] F. Cassot, V. Vergeur, P. Bossuet, B. Hillen, M. Zagzoule, J.P. Marc-Vergnes: “Effects of anterior communicating artery diameter on cerebral hemodynamics in internal carotid artery disease. A model study”. Circulation, vol. 92, no. 10, Nov 1995, pp. 3122-3131.
• [6] B. Hillen, H.W. Hoogstraten, L. Post: “A mathematical model of the flow in the circle of Willis”. Biomech., vol. 19, no. 3, 1986, pp. 187-194.
• [7] A. Ferrández, T. David, M.D. Brown: “Numerical models of auto-regulation and blood flow in the cerebral circulation”. Comput Methods Biomech Biomed Engin, vol. 5, no. 1, Feb. 2002, pp. 7-19.
• [8] S.M. Moore, K.T. Moorhead, J.G. Chase, T. David, J. Fink: “One-dimensional and three-dimensional models of cerebrovascular flow”. J Biomech Eng, vol. 127, no. 3, Jun. 2005, pp. 440-449.
• [9] S.M. Moore, T. David, J.G. Chase, J. Arnold, J. Fink: “3D models of blood flow in the cerebral vasculature”. J Biomech, vol. 39, no. 8, 2006, pp. 1454-1463.
• [10]N. Westerhof, N. Stergiopulos: “Models of the arterial tree”. Stud Health Technol Inform, 2000, vol. 71, pp. 65-77.
• [11]M. Schwarz, M.P. Nguyen, U. Kiencke, C. Heilmann, R. Klemm, C. Benk, F. Beyersdorf, H.J. Busch: “Integration of the Circle of Willis into Avolio’s Model of the Arterial Haemodynamics”. Proceedings of the Sixth IASTED International Conference on Biomedical Engineering, Innsbruck, Austria, 2008, pp. 193-198.
• [12]R. Prêtre, M.I. Turina: Deep Hypothermic Circulatory Arrest. vol. 2, 2003, pp. 401-412.
• [13]H. Stephan: Cerebral effects of hypothermic extracorporeal circulation. Springer-Verlag, 1991. (in German)
• [14]M. Karamanoglu, D.E. Gallagher, A.P. Avolio, M.F. O’Rourke: “Functional origin of reflected pressure waves in a multibranched model of the human arterial system”. Am J Physiol, vol. 267, no. 5, Pt 2, Nov. 1994, pp. H1681-H1688.
• [15]E. Naujokat, U. Kiencke: “Observation of the patient’s state in cardiac surgery”. vol. 50 no. 5, pp. 204-211, 2002. (in German)
• [16]M.C. Lewis: “Hypothermia”. Anesthesiology Online, 1998.
• [17]D.W. Newell, R. Aaslid, A. Lam, T.S. Mayberg, H.R. Winn: “Comparison of flow and velocity during dynamic autoregulation testing in humans”. Stroke, vol. 25, no. 4, Apr. 1994, pp. 793-797.
• [18]K.T. Moorhead, C.V. Doran, J.G. Chase, T. David: “Lumped parameter and feedback control models of the auto-regulatory response in the Circle of Willis”. Comput Methods Biomech Biomed Engin, vol. 7, no. 3, Jun. 2004, pp. 121-130.
• [19]K.T. Moorhead, J.G. Chase, T. David, J. Arnold: “Metabolic model of autoregulation in the Circle of Willis”. J Biomech Eng, vol. 128, no. 3, Jun 2006, pp. 462-466.
• [20]A.C. Guyton, J.E. Hall: Textbook of medical physiology. Saunders, 1996.
• [21]S. Silbernagl, A. Despopoulos: Pocket atlas of physiology. 1991. (in German)
• [22]A.M. Grigore, L.Jr. Brusco: “Temperature regulation and manipulation during surgery and anesthesia”. Anesthesiology Online Journal, vol. 5, 1998.
• [23]A. Kurz, D.I. Sessler, F. Birnbauer, U.M. Illievich, C.K. Spiss: “Thermoregulatory vasoconstriction impairs active core cooling”. Anesthesiology, vol. 82, no. 4, Apr 1995, pp. 870-876.
• [24]D. Fiala, K.J. Lomas, M. Stohrer: “A computer model of human thermoregulation for a wide range of environmental conditions: the passive system”. J Appl Physiol, vol. 87, no. 5, Nov. 1999, pp. 1957-1972.
• [25]R.G. Gordon, R.B. Roemer, S.M. Horvath: “A Mathematical Model of the Human Temperature Regulatory System - Transient Cold Exposure Response”. IEEE Transactions on Biomedical Engineering, vol. 23, no. 6, 1976, pp. 434-444.
• [26]J.A.J. Stolwijk, J.D. Hardy: “Temperature regulation in man - a theoretical study”. Pflügers Arch Gesamte Physiol Menschen Tiere, vol. 291, no. 2, 1966, pp. 129-162.
• [27]X. Xu, J. Werner: “A Dynamic Model of the Human/Clothing/Environment-System”. Appl Human Sci, vol. 46, no. 2, 1997, pp. 61-75.
• [28]F.B. Sachse, C.D. Werner, M. Müller, K. Meyer-Waarden: “Preprocessing of the Visible Man dataset for the generation of macroscopic anatomical models”. Proc. First Users Conference of the National Library of Medicine’s Visible Human Project, 1996.
• [29]F.B. Sachse, M. Glas, M. Müller, K. Meyer-Waarden: “Segmentation and tissue-classification of the Visible Man dataset using the computertomographic scans and the thin-section photos”. Proc. First Users Conference of the National Library of Medicine’s Visible Human Project, 1996.
• [30]D. Fiala, K.J. Lomas, M. Stohrer: “Computer prediction of human thermoregulatory and temperature responses to a wide range of environmental conditions”. Int J Biometeorol, vol. 45, no. 3, Sep. 2001, pp. 143-159.