A multi-method approach to measurement of respiratory system mechanics

• Autorzy: Polak A. G. , Wysoczański D. , Mroczka J.

Warianty tytułu

PL

Wielometodowe podejście do pomiarów właściwości mechanicznych układu oddechowego

• Języki publikacji: EN

Abstrakty

EN

A multi-method system developed for complex investigations of lung mechanics is described. The system includes complementary measurement techniques such as forced oscillations, interrupter technique, methods for measurement of pulmonary mechanics during artificial ventilation and spirometry. These techniques are completed by computational models enabling an analysis of the relation between the lung structure, function, pathology and measurement results. This set-up is a first step towards a new-quality approach to research into the respiratory system via multi-method fusion.

PL

Układ oddechowy jest podstawowym systemem podtrzymującym funkcje życiowe organizmu człowieka. Wysoce złożona budowa płuc i wielorakość zachodzących w nich procesów powodują, że opracowano wiele metod badania układu oddechowego. Obejmują one zarówno techniki pomiarowe jak i modelowanie matematyczne. Każda z metod dostarcza innego zasobu informacji o płucach. Wydaje się, że ich połączenie może stanowić podstawę jakościowo nowego podejścia w badaniach nad układem oddechowym. Z tego też powodu zbudowano system łączący kilka uzupełniających się technik pomiarowych, takich jak wymuszone oscylacje, przerywanie przepływu powietrza, pomiar właściwości mechanicznych płuc podczas sztucznej wentylacji i spirometria. Techniki te wzbogacone zostały o zaimplementowane modele komputerowe płuc działających w różnych warunkach, pozwalające analizować związki pomiędzy ich strukturą, funkcjonowaniem, zachodzącymi procesami patologicznymi i wynikami pomiarów Skonstruowany system stanowi pierwszy krok w kierunku bardziej szczegółowego, wiarygodnego i wyczerpującego zrozumienia funkcjonowania układu oddechowego, bazującego na fuzji wyników wielu metod badawczych.

Słowa kluczowe

EN

pulmonary mechanics; forced oscillations; mechanical ventilation; interrupter technique; spirometry; computational model; multi-method fusion

PL

właściwości mechaniczne płuc; wymuszone oscylacje; sztuczna wentylacja; przerywanie przepływu powietrza; spirometria; modelowanie matematyczne; fuzja wielometodowa

• Wydawca: Komitet Metrologii i Aparatury Naukowej PAN
• Czasopismo: Metrology and Measurement Systems
• Rocznik: 2006
• Tom: Vol. 13, nr 1
• Strony: 3--17
• Opis fizyczny: Bibliogr. 52 poz., rys., wykr.

Twórcy

autor

Polak A. G.

autor

Wysoczański D.

autor

Mroczka J.

• Wroclaw University, Chair of Electronic and Photonic Metrology, Poland,

Bibliografia

• 1. Weibel E.R., Sapoval B., Filoche M.: Design of peripheral airways for efficient gas exchange. Respir. Phys. Neurobiol., vol. 148, no. 1-2, 2005, pp. 3-21.
• 2. Weibel E.R.: Morphometry of the Human Lung. Berlin, Springer 1963.
• 3. Horsfield K., Dart G., Olson D.E., Cumming G.: Models of the human bronchial tree. J. Appl. Physiol., vol. 31, no. 2, 1971, pp. 207-217.
• 4. Venegas, J.G., et al.: Self-organized patchiness in asthma, a prelude to catastrophic shifts? Nature, vol. 434, no. 7034, 2005, pp. 777-782.
• 5. DuBois A.B., Brody A.W., Lewis D.H., Burgess B.F. Jr.: Oscillation mechanics of lungs and chest in man. J. Appl. Physiol., vol. 8, no. 6, 1956, pp. 587-594.
• 6. Peslin R., Duvivier C., Gallina C.: Total respiratory input and transfer impedances in humans. J. Appl. Physiol., vol. 59, no. 2, 1985, pp. 492-501.
• 7. Michaelson E.D., Grassman E.D., Peters W.R.: Pulmonary mechanics by spectral analysis of forced random noise. J. Clin. Invest., vol. 56, no. 5, 1975, pp. 1210-1230.
• 8. Lutchen K.R., Everett J.R., Jackson A.C.: Impact of frequency range and input impedance on airway-tissue separation implied from transfer impedance. J. Appl. Physiol., vol. 74, no. 3, 1993, pp. 1089-1099.
• 9. Tomalak W., Peslin R., Duvivier C.: Respiratory tissue properties derived from flow transfer function in healthy humans. J. Appl. Physiol., vol. 82, no. 4, 1997, pp. 1098-1106.
• 10. Tomalak W., Peslin R., Duvivier C.: Variations in airways impedance during respiratory cycle derived from combined measurements of input and transfer impedances. Eur. Respir. J., vol. 12, no. 6, 1998, pp. 1436-1441.
• 11. Jensen A., Atileh H., Suki B., Ingenito E.P., Lutchen K.R.: Selected contribution: airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations. J. Appl. Physiol., vol. 91, no. 1, 2001, pp. 506-515.
• 12. Suki B., Habib R.H., Jackson A.C.: Wave propagation, input impedance, and wall mechanics of the calf trachea from 16 to 1,600 Hz. J. Appl. Physiol., vol. 75, no. 6, 1993, pp. 2755-2766.
• 13. Guszkowski T., Polak A.G., Mroczka J., Wszoła W.: Optimization of forced oscillation phases by means of a genetic algorithm. XII Scientific Conference „Biocybernetics and Bioengineering”, Warszawa, November 28-30, 2001, pp. 390-393. (in Polish)
• 14. Wysoczański G., Polak A.G., Mroczka J.: A computer-based system for measurement of respiratory system properties with the use of high-frequency forced oscillations. Congress of Metrology KM 2004, Wrocław, September 6-9, 2004, pp. 619-622. (in Polish)
• 15. Suki B., Lutchen K.R.: Pseudorandom signals to estimate apparent transfer and coherence functions of nonlinear systems: applications to respiratory mechanics. IEEE Trans. Biomed. Eng., vol. 39, no. 11, 1992, pp. 1142-1151.
• 16. Wysoczański D., Polak A.G., Mroczka J.: A computer-based system for measurement of respiratory system properties with the use of low-frequency forced oscillations. Congress of Metrology KM 2004, Wrocław, September 6-9, 2004, pp. 611-614. (in Polish)
• 17. Lauzon A.M., Bates J.H.T.: Estimation of time-varying respiratory mechanical parameters by recursive least squares. J. Appl. Physiol., vol. 71, no. 3, 1991, pp. 1159-1165.
• 18. Avanzolini G., Barbini P., Cappello A., Cevenini G.: Influence of flow pattern on the parameter estimates of a simple breathing mechanics model. IEEE Trans. Biomed. Eng., vol. 42, no. 4, 1995, pp. 394-402.
• 19. Barbini P., Cevenini G., Bernardi F., Massai M.R., Gnudi G., Avanzolini G.: Effect of compliant intermediate airways on total respiratory resistance and elastance in mechanical ventilation. Med. Eng. Phys., vol. 23, no. 3, 2001, pp. 185-194.
• 20. Vassiliou M.P., et al.: Volume and flow dependence of respiratory mechanics in mechanically ventilated COPD patients. Respir. Physiol. Neurobiol., vol. 135, no. 1, 2003, pp. 87-96.
• 21. Polak A.G., Mroczka J. Pukacz A: A recursive algorithm for estimation of respiratory system parameters during mechanical ventilation. Congress of Metrology KM 2004, Wrocław, September 6-9, 2004, pp. 607-610. (in Polish)
• 22. Polak A.G., Mroczka J.: A method for estimation of time-varying properties of the respiratory system using the prior knowledge. Congress of Metrology KM 2004, Wrocław, September 6-9, 2004, pp. 577-580. (in Polish)
• 23. Peslin R., Felicio da Silva J., Duvivier C., Chabot F.: Respiratory mechanics studied by forced oscillations during artificial ventilation. Eur. Respir. J., vol. 6, no. 6, 1993, pp. 772-784.
• 24. Lutchen K.R., Yang K., Kaczka D.W., Suki B.: Optimal ventilatory waveform for estimating low frequency mechanical impedance. J. Appl. Physiol., vol. 75, no. 1, 1993, pp. 478-488.
• 25. Kaczka D.W., Ingenito E.P., Lutchen K.R.: Technique to determine inspiratory impedance during mechanical ventilation: implications for flow limited patients. Ann. Biomed. Eng., vol. 27, no. 3, 1999, pp. 340-355.
• 26. Polak A.G., Woźny Z., Mroczka J.: Validation of the algorithm for estimation of respiratory impedance during mechanical ventilation by the EVW. VIII Symposium „Modelling and Measurements in Medicine”, Krynica, May 14-18, 2006. (submitted, in Polish)
• 27. Neergaard J. von, Wirz K.: Die Messung der Strömungswiderstände in den Atemwegen des Menschen, insbesondere bei Asthma und Emphysem. Z. Klin. Med., vol. 105, 1927, pp. 51-82.
• 28. Romero P.V., Sato J., Shardonofsky F., Bates J.H.T.: High frequency characteristics of respiratory mechnaics determined by flow interruption. J. Appl. Physiol., vol. 69, no. 5, 1990, pp. 1682-1688.
• 29. Frey U., Schibler A., Kraemer R.: Pressure oscillations after flow interruption in relation to lung mechanics. Respir. Physiol., vol. 102, no. 2-3, 1995, pp. 225-237.
• 30. Frey U., Kraemer R.: Oscillatory pressure transients after flow interruption during bronchial challenge test in children. Eur. Respir. J., vol. 10, no. 1, 1997, pp. 75-81.
• 31. Frey U., Suki B., Kraemer R., Jackson A.C.: Human respiratory input impedance between 32 and 800 Hz, measured by interrupter technique and forced oscillations. J. Appl. Physiol., vol. 82, no. 3, 1997, pp. 1018-1023.
• 32. Polak A.G., Jabłoński I., Mroczka J.: Reduction of a mathematical model for the respiratory system during flow interruption. XI Scientific Conference „Biocybernetics and Bioengineering”, Warszawa, December 2-4, 1999, pp. 65-69. (in Polish)
• 33. Jabłoński I., Polak A.G., Mroczka J.: Methods of identification of the respiratory system after flow interruption. PAK, vol. 8, 2000, pp. 18-22. (in Polish)
• 34. Hyatt R.E.: Expiratory flow limitation. J. Appl. Physiol., vol. 55, no. 1, 1983, pp. 1-7.
• 35. Quanjer P.H., Tammeling G.J., Cotes J.E., Pedersen O.F., Peslin R., Yernault J.-C. Lung volume and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur. Respir. J., vol. 6, suppl. 16, 1993, pp. 5-40.
• 36. American Thoracic Society. Standardization of spirometry, 1994 update. Am. J. Respir. Crit. Care Med., vol. 152, no. 3, 1995, pp. 1107-1136.
• 37. Miller M.R., et al.: Standardisation of spirometry. Eur. Respir. J., vol. 26, no. 2, 2005, pp. 319-338.
• 38. Roca J., et al.: References values for forced spirometry. Group of the European Community Respiratory Health Survey. Eur. Respir. J., vol. 11, no. 6, 1998, pp. 1354-1362.
• 39. Mroczka J.: Metrology in the process of cognition. In: Barzykowski J. (Ed.): Contemporary Metrology – Selected Problems. Warszawa, WNT 2004. (in Polish)
• 40. Bates J.H., Lutchen K.R.: The interface between measurement and modeling of peripheral lung mechanics. Respir. Physiol. Neurobiol., vol. 148, no. 1-2, 2005, pp. 153-164.
• 41. Lutchen K.R., Greenstein J.L., Suki B.: How inhomogeneities and airway walls affect frequency dependence and separation of airway and tissue properties. J. Appl. Physiol., vol. 80, no. 5, 1996, pp. 1696-1707.
• 42. Polak A.G., Adamusiak Ł., Mroczka J.: Impact of airway compliance on measurement of respiratory mechanics by forced oscillations. Proceedings of the VII Symposium „Modelling and Measurements in Medicine”, Krynica, May 8-12, 2005, pp. 49-54. (in Polish)
• 43. Polak A.G., Mroczka J.: Nonlinear model for mechanical ventilation of human lungs. Compt. Biol. Med., vol. 36, no. 1, 2006, pp. 41-58.
• 44. Polak A.G., Grześkowiak B., Mroczka J.: Measurement of respiratory system properties during mechanical ventilation with the use of neural networks. VIII Symposium „Modelling and Measurements in Medicine”, Krynica, May 14-18, 2006. (submitted, in Polish)
• 45. Golden J.F., Clark J.W. Jr, Stevens P.M.: Mathematical modeling of pulmonary airway dynamics. IEEE Trans. Biomed. Eng., vol. 20, no. 6, 1973, pp. 397-404.
• 46. Barbini P., Cevenini G., Avanzolni G.: Nonlinear mechanisms determining expiratory flow limitation in mechanical ventilation: a model-based interpretation. Ann. Biomed. Eng., vol. 31, no. 8, 2003, pp. 908-916.
• 47. Polak A.G., Mroczka J.: Computational model for mechanical ventilation of a patient. Congress of Metrology KM 2004, Wrocław, September 6-9, 2004, pp. 603-606.
• 48. Polak A.G., Lutchen K.R.: Computational model for forced expiration from asymmetric normal lungs. Ann. Biomed. Eng., vol. 31, no. 8, 2003, pp. 891-907.
• 49. Polak A.G., Mroczka J.: Model analysis of the choke points arrangement during forced expiration. 6th IFAC Symposium on Modelling and Control in Biomedical Systems, Reims, September 20-22, 2006 (submitted).
• 50. Lambert R.K., Wilson T A., Hyatt R E., Rodarte J.R.: A computational model for expiratory flow. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol., vol. 52, no. 1, 1982, pp. 44-56.
• 51. Polak A.G.: A forward model for maximum expiration. Comp. Biol. Med., vol. 28, no. 6, 1998, pp. 613-625.
• 52. Morlion B., Polak A.G.: Simulation of lung function evolution after heart-lung transplantation using a numerical model. IEEE Trans. Biomed. Eng., vol. 52, no. 7, 2005, pp. 1180-1187.