Assessment of human motoneuron afterhyperpolarization duration in health and disease

• Autorzy: Piotrkiewicz M. , Kudina L. , Jason Chen J. J. , Hausmanowa-Petrusewicz I.
• Języki publikacji: EN

Abstrakty

EN

The results of the investigatigation of afterhyperpolarization (AHP) duration in normal aging and selected neuromuscular disorders are presented. This investigation yielded unexpected results: the AHP shortening in myogenic disease (DMD) and no significant difference from control values in neurogenic disease (ALS). However, introduction of age factor revealed novel aspects of the human ALS, which can be interpreted on the basis of the results obtained in a SOD1 mice, thus confirming usefulness of this animal model of ALS. In spastic patients the AHP was prolonged and the difference from the control AHP duration decreased with age and disease duration. Our results suggest that the match between temporal characteristics of the AHP of MN and of the twitch of its muscle unit is preserved during normal aging and in spasticity, but not in the DMD.

Słowa kluczowe

EN

human motoneurone; afterhyperpolarization; aging; duchenne muscular dystrophy; amyotrophic lateral sclerosis; post stroke spasticity

PL

neuron ruchowy ludzki; starzenie się; dystrofia mięśni; stwardnienie zanikowe boczne; spastyczność po udarze

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2012
• Tom: Vol. 32, no. 3
• Strony: 43--61
• Opis fizyczny: Bibliogr. 63 poz., wykr.

Twórcy

autor

Piotrkiewicz M.

autor

Kudina L.

autor

Jason Chen J. J.

autor

Hausmanowa-Petrusewicz I.

• Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, ul. Ks. Trojdena 4, 02-109 Warsaw, Poland,

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