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A hybrid (hydro-numerical) cardiovascular model: application to investigate continuous-flow pump assistance effect

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EN
Abstrakty
EN
A hybrid (Hydro-numerical) model of blood circulation developed at the Institute of Biocybernetics and Biomedical Engineering (IBIB) of the Polish Academy of Sciences (PAN) -Warsaw, Poland, in co-operation with the Institute of Clinical Physiology (IFC) of the National Council of Research (CNR) - Rome, Italy, is a basic model of this type solutions commonly accepted by the researchers. It is able to simulate all essential hemodynamic functions of the human cardiovascular system including the heart. During last years, resumption of works on constant-flow non pulsatile rotary pumps to be used as heart support devices is observed because of their small dimensions and easier way of implantation. Control modes of rotary pumps are different and evidently influence heart support effects. The main aim of this paper was to investigate different control systems of rotary pumps in a role of the assist devices. To fulfill this task on the hybrid model, a special computer application was worked out. The investigations included: a) loading characteristics p(q) of the rotary pump assignment at two values of a control voltage - 18V, 24V; b) physiological and pathological states simulation including parallel atrial-aortic assistance by the rotary pump. The results of the simulations obtained on the model treated as a 'virtual patient' are in agreement with the data received in medical conditions.
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autor
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  • Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, ul. Księcia Trojdena 4, 02-109 Warsaw, Poland, krystyna.gorczynska@ibib.waw.pl
Bibliografia
  • [1] Meyns B.P., Klotz S., Simon A., Droogne W., Rega F., Griffith B. et al.: Hemodynamic Response to Long -Term Partial Ventricular Support with the Synergy Pocket Micro–Pump. J. Am. Coll. Cardiol., Elsevier Inc. 2009, 54, 1, 79–86.
  • [2] Meyns B.P., Simon A., Klotz S., Wittwer T. et al.: Clinical benefits of partial circulatory supporting, New York Heart Associacion Class IIIB and early Class IV patients, Elsevier Eur., J. Cardio-Thor. Surg. 2011, 39, 693–698.
  • [3] Slaughter M.S., Rogers J.G. et al.: Advanced Heart Failure Treated with Continuous - Flow Left Ventricular Assist Device. N. Engel. J. Med. 2009, 361, 2241–2251.
  • [4] Kozarski M., Gianfranco G., Darowski M., Zieliński K., Pałko K.J.: Comprehensive models of cardiovascular and respiratory systems, Chapter 8: Physical ad hybrid models: Hybrid models, Nova Science Publ. Inc., New York, 2010, 217–235.
  • [5] Kozarski M., Ferrari G., Darowski M., Gorczyńska K., Clemente F., Pałko K.J.: The electrohydraulic impedance converter in mock circulatory system design. Biocybernetics and Biomedical Engineering 2003, 23, 2, 27–34.
  • [6] Gorczyńska K.: Circulatory Assistance: Basic Classification of Heart Assistance Methods and Devices, Biocybernetics and Biomedical Engineering 2011, 31, 1, 3–15.
  • [7] Garcia S., Kandar F., Boyle A., Colvin-Adams M. et al.: Effect of Pulsatile and Continuous-flow Left Ventricular Assist Devices on Left Ventricular Unloading. J. Heart and Lung Trans. 2008, 22, 3, 261–267.
  • [8] Morita S., Kormos R.L., Mandarino W.A. et al.: Right ventricular/arterial coupling in the patient with left ventricular assistance. Circulation 86 (Suppl 2), 1992, II-316-25.
  • [9] Miyamoto Y., Kormos R.L., Borovetz H.S. et al.: Hemodynamic Parameters Influencing Clinical performance of Novacor Left Ventricular Assist System. Artif. Org. 1990, 14 (6), 454–457.
  • [10] Sagawa K., Maugham L., Suga H., Sunagawa K.: Cardiac Contraction and the Pressure-Volume Relationship. Oxford Univ. Press, 1988.
  • [11] Morley D., Litwak K., Ferber P. Spence P., Dowling R., Meyns B. et al.: Hemodynamic effects of partial ventricular support in chronic heart failure: Results of simulation validated with in vivo data. J. Thorac. Cardiol. Surg. 2007, 133, 21–28.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPZ6-0001-0016
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