Physiological roles for persistent inward currents in motoneurones: insights from the Central Respiratory Drive

• Autorzy: Kirkwood P. , Denton M. E. , Wienecke J. , Nielsen J. , Hultborn H.
• Języki publikacji: EN

Abstrakty

EN

The roles of persistent inward currents in amplifying synaptic currents in motoneurone dendrites are now widely recognized as of vital importance. Here we describe how one particular synaptic input, the respiratory drive to hindlimb motoneurones, not only demonstrates an extreme example of this amplification, but also reveals the operation of ongoing, dynamic modulatory controls of the amplification from central sources.

Słowa kluczowe

EN

spinal motoneurones; respiratory drive; plateau potentials; persistent inward; cardiovascular control; synaptic modulation

PL

motoneuron rdzeniowy; układ sercowo-naczyniowy; modulacja synaptyczna

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2005
• Tom: Vol. 25, no. 3
• Strony: 31--38
• Opis fizyczny: Bibliogr. 13, rys.

Twórcy

autor

Kirkwood P.

• Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N3BG, UK

autor

Denton M. E.

• Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK

autor

Wienecke J.

• Departament of Medical Physiology, University of Copenhagen, Panum Institute, Copenhagen N, Denmark

autor

Nielsen J.

• Departament of Medical Physiology, University of Copenhagen, Panum Institute, Copenhagen N, Denmark

autor

Hultborn H.

• Departament of Medical Physiology, University of Copenhagen, Panum Institute, Copenhagen N, Denmark

Bibliografia

• [1] Powers R.K and Binder M.D.: Input-output functions of mammalian motoneurons. Rev. Physiol. Biochem. Pharmacol. 2001, 143, 137-263.
• [2] Conway B.A., Hultborn H., Kiehn O. and Mintz I.: Plateau potentials in a-motoneurones induced by intravenous injection of L-DOPA and clonidine in the spinal cat. J. Physiol. 1988, 405, 369-384.
• [3] Heckman C.J., Gorassini M.A. and Bennett D.J.: Persistent inward currents in motoneuron dendrites: implications for motor output. Muscle and Nerve 2005, 31, 135-156.
• [4] Meyer-Lohman J.: Respiratory influences upon the lumbar extensor motor system of decerebrated cats, In: W. Umbach and H.P. Koepchen (Eds.). Central Rhythmic and Regulation, Hippokrates Verlag Stuttgart 1974, 334-341.
• [5] Kirkwood P.A., Lawton M. and Ford T.W.: Plateau potentials in hindlimb motoneurones of female cats under anaesthesia. Exp. Brain Res. 2002., 146, 399-403.
• [6] Hultborn H.: Plateau potentials and their role in regulating motoneuronal firing. In: M. Binder (Ed.). Peripheral and Spinal Mechanisms in the Neural Control of Movement, Progress in Brain Research, Vol. 123 Elsevier, Amsterdam 1999, 39-48.
• [7] Guertin P.A. and Hounsgaard J.: Non-volatile anaesthetics reduce spinal activity by suppressing plateau potentials. Neurosci. 1999, 88, 353-358.
• [8] Schwindt P. and Crill W.: Role of persistent inward current in motoneuron bursting during spinal seizures. J. Neurophysiol. 1980, 43, 1296-1318.
• [9] Sears T.A.: The slow potentials of thoracic respiratory motoneurones and their relation to breathing. J. Physiol. 1964, 175,404-424.
• [10] Malpas S.C.: Neural influences on cardiovascular variability: possibilities and pitfalls Am.J. Physiol. Heart Circ. Physiol. 2002, 282, H6-H20.
• [11] Heymans C. and Bouckeart J.J.: Sinus caroticus and respiratory reflexes. J. Physiol. 1930, 69, 254-266.
• [12] Bainton C.R. and Kirkwood P.A.: The effect of carbon dioxide on the tonic and rhythmic discharges of expiratory bulbospinal neurones. J. Physiol. 1979, 296, 291-314.
• [13] Bennett D.J., Hultborn H., Fedirchuck B. and Gorassini M.: Synaptic excitation of plateaus in hindlimb motoneurons of decerebrate cats. J. Neurophysiol. 1998, 80, 2023-2037.