Frequency analysis of ictal EEG neocortical epileptic discharges in cats: comparison between potassium and penicillin induced seizures

• Autorzy: Sobieszek A. , Tarnecki R. , Zalewska E.
• Języki publikacji: EN

Abstrakty

EN

Results of this research illustrate similarities as well as differences between patterns of the cortical EEG ictal discharges and their frequency spectra recorded in two experimental, animal models of epilepsy in cats. Localized bioelectric discharges were evoked in animals with permanently implanted electrodes either by local, subdural. epicortical application of penicillin or subdural perfusion of the parietal cortex with artificial cerebrospinal fluid (aCSF) with elevated concentration of potassium ions up to 16 mM/dcm3. Three classes of components were distinguished: low frequency surface negative spikes and surface positive waves with subsequent negativity, appearing at theta-delta frequencies (2-4 Hz), recorded in both experimental conditions and high frequency component in beta frequency range (13-35 Hz) recorded after administration of penicillin. A typical pattern of spike and slow wave complexes was characteristic for ictal discharges evoked by high potassium aCSF. High frequency "beta" component was observed after topical administration of penicillin and was preserved after administration of substances belonging to the two classes of potent antiepileptic drugs: barbiturates and benzodiazepines. The results provide experimental evidence linking disturbances of the neuronal potassium ion homeostasis in the cerebral cortex with the appearance of EEG spike and slow wave pattern characteristic for absence epilepsy.

Słowa kluczowe

EN

ictal discharges; electrocardiography; frequency analysis; epilepsy models

PL

epilepsja; elektrokardiografia; analiza częstotliwościowa; potas; penicylina

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2005
• Tom: Vol. 25, no. 1
• Strony: 37--47
• Opis fizyczny: Bibliogr. 22 poz., rys.

Twórcy

autor

Sobieszek A.

• Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Science, 02-109 Warszawa, ul. Ks. Trojdena 4, Poland

autor

Tarnecki R.

• Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Science, 02-109 Warszawa, ul. Ks. Trojdena 4, Poland

autor

Zalewska E.

• Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Science, 02-109 Warszawa, ul. Ks. Trojdena 4, Poland

Bibliografia

• [1] Barth D.S., Shi Di, Baumgartner C.: Laminar cortical interactions during epileptic spikes studied with principal component analysis and physiological modeling. Brain Res., 1989, 484, 13-35.
• [2] Chagnac-Amitai Y., Connors B.W.: Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex. J. Neurophysiol., 1989, 62, 1149-1162.
• [3] DeFelipe J., Alonso-Nanclares L., Arellano J.I.: Microstructure of the neocortex: comparative aspects. J. Neurocytol., 2002, 31, 299-316.
• [4] Desroches A.M., Chapelle D., Laget P.: Ontogenesis of Cortical Unit Activity Located in a Penicillin- Induced Focus in the Rabbit. In: N. Chalanzonitis and M. Boisson (Eds.), Abnormal Neuronal Discharges, Raven Press, New York 1978, 91-102.
• [5] Douglas R.J., Martin K.A.C., Whitteridge D.: A Canonical Microcircuit for Neocortex. Neural Computation, 1989, 1, 480-488.
• [6] Fischer R.S.: Animal models of the epilepsies. Brain Res. Rev., 1989, 14, 245-278.
• [7] Glaser G.H.: Experimental Derangements of Extracellular Ionic Environment. In: D P. Purpura, J.K. Penry, D.B. Tower, D.M. Woodbury, R.D. Walter (Eds.), Experimental Models of Epilepsy. Raven Press. 1972. 317-345.
• [8] Gloor P., Quesney L.F., Zumstein H.: Pathophysiology of generalized penicillin epilepsy in the c; The role of cortical and subcortical structures. II. Topical application of penicillin to the cerebral ai to subcortical structures. Electroencephalogr. Clin. Neurophysiol., 1977,43, 79-94.
• [9] Gloor P., Fariello R.G.: Generalized epilepsy: some of its cellular mechanisms differ from those focal epilepsy. TINS, 1988,11, 63-68.
• [10] Goldensohn E.G.: Initiation and Propagation of Epileptogenic Foci. In: Penry J.K. and Daly D.D.(Eds Complex Partial Seizures and Their Treatment, Adv. Neurol., Vol. 11, Raven Press, New York, 1975 141-161.
• [11] Heinemann U., Lux H.D., Gutnick M.J.: Extracellular free calcium and potassium during paroxysmal activity in the cerebral cortex of the cat. Exp. Brain Res., 1977, 27, 237-243.
• [12] McComas A.J., Cupido C.M.: The RULER model. Is this how the somatosensory cortex works? Clin. Neurophysiol., 1999, 110, 1987-1994.
• [13] Peters A.: Examining neocortical circuits: some background and facts. J. Neurocytol., 2002,31, 183-193.
• [14] Pockberger H., Rappelsberger P., Petsche H.: Penicillin-induced epileptic phenomena in the rabbit's neocortex I. The development of interictal spikes after epicortical application of penicillin. Brain Res., 1984a, 309, 247-260.
• [15] Pockberger H., Rappelsberger P., Petsche H.: Penicillin-induced epileptic phenomena in the rabbit's neocortex II. Laminar specific generation of interictal spikes after application of penicillin to different cortical depth. Brain Res., 1984b, 309, 261-269.
• [16] Schubert D., Staiger J.F., Cho N., Kotter R., Zilles K., Luhmann H.J.: Layer-specific intracolumnar and transcolumnar functional connectivity of layer V pyramidal cells in rat barrel cortex. J. Neurosci., 2001, 21,3580-3592.
• [17] Silva L.R., Amitai Y., Connors B.W.: Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. Science, 1991, 251, 432-435.
• [18] Sobieszek A., Chwojnowski A.: Neocortical EEG discharges and epileptic seizures due to subdural perfusion with potassium rich artificial cerebrospinal fluid in cats with permanently implanted electrodes. Epileptologia, 2000, 8, Suppl. 1, 134-135.
• [19] Timofeev I., Bashenov M., Sejnowski T., Steriade M.: Cortical hyperpolarization activated depolarizing current takes part in the generation of focal paroxysmal activities. PNAS, 2002, 99, 9533-9537.
• [20] Thomson A.M., Bannister A.P.: Postsynaptic pyramidal target selection by descending layer III pyramidal axons: dual intracellular recordings and biocytin filling in slices of rat neocortex. Neuroscience 1998, 84, 669-683.
• [21] Thomson A.M., Bannister A.P.: Interlaminar connections in the neocortex. Cereb. Cortex., 2003, 13, 5-14.
• [22] Thomson A.M., West D C., Wang Y., Bannister A.P.: Synaptic connections and small circuits involving excitatory and inhibitory neurons in layers 2-5 of adult rat and cat neocortex: triple intracellular recordings and biocytin labeling in vitro. Cereb. Cortex., 2002.12, 936-953.