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Abstrakty
Software allowing visualization of D-optimal objective function distribution over multidimensional time space was designed and implemented. The analysis was performed for one, two and three-compartmental models. Outputs of the models have form of sums of exponential terms. The exemplary objective functions distribution and searching algorithm are presented. The obtained results show that objective function for D-optimal solution has no local extremes. The problem under investigation has one globally optimal solution.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
Strony
23--36
Opis fizyczny
Bibliogr. 7 poz., rys.
Twórcy
autor
- Technical University of Gdańsk, ul. Narutowicza 11/12, 80-952 Gdańsk, Poland
autor
- Białystok Technical University, Poland
Bibliografia
- [1] Cobelli C., Ruggeri A., DiStefano J., Landaw E.: Optimal design of multioutput sampling schedules - Software and applications to endocrine-metabolic and pharmacokinetic models, IEEE Transactions: on Biomedical Engineering, 1985, 32, 4, 249-256.
- [2] D’Argenio D.: Optimal sampling times for pharmacokinetic experiments, Journal of Pharmacokinetics and Biopharmaceutics, 1981, 9, 6, 740-756.
- [3] DiStefano J.: Algorithms, software and sequential optimal sampling schedule design for pharmacokinetic and physiologic experiments, Mathematics Computer Simulation, 1 531-534.
- [4] Eykhoff P.: System Identification and State Estimation, PWN, Warszawa 1980.
- [5] Kalicka R.: Optimal Multicompartmental Experiment Design, Task Quarterly, Scientific Bulletin of Academic Computer Centre in Gdansk, Gdansk 1997, 1, 2, 209-221.
- [6] Kalicka R.: Optimal design and organization of biomedical experiment, Measurement, 1999, 26, 19-44.
- [7] Walter E., Pronzato L: Qualitative and Quantitative Experiment Design for Phenomenological Models, Automatica, 1990, 26, 2, 195-213.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPZ3-0006-0063