Properties of D-optimal sampling schedule for compartmental models

• Autorzy: Kalicka R. , Bochen D.
• Języki publikacji: EN

Abstrakty

EN

Software allowing visualization of D-optimal objective function distribution over multidimensional time space was designed and implemented. The analysis was performed for one, two and three-compartmental models. Outputs of the models have form of sums of exponential terms. The exemplary objective functions distribution and searching algorithm are presented. The obtained results show that objective function for D-optimal solution has no local extremes. The problem under investigation has one globally optimal solution.

Słowa kluczowe

EN

D-optimal sampling schedule; compartmental models

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2005
• Tom: Vol. 25, no. 1
• Strony: 23--36
• Opis fizyczny: Bibliogr. 7 poz., rys.

Twórcy

autor

Kalicka R.

• Technical University of Gdańsk, ul. Narutowicza 11/12, 80-952 Gdańsk, Poland

autor

Bochen D.

• Białystok Technical University, Poland

Bibliografia

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• [2] D’Argenio D.: Optimal sampling times for pharmacokinetic experiments, Journal of Pharmacokinetics and Biopharmaceutics, 1981, 9, 6, 740-756.
• [3] DiStefano J.: Algorithms, software and sequential optimal sampling schedule design for pharmacokinetic and physiologic experiments, Mathematics Computer Simulation, 1 531-534.
• [4] Eykhoff P.: System Identification and State Estimation, PWN, Warszawa 1980.
• [5] Kalicka R.: Optimal Multicompartmental Experiment Design, Task Quarterly, Scientific Bulletin of Academic Computer Centre in Gdansk, Gdansk 1997, 1, 2, 209-221.
• [6] Kalicka R.: Optimal design and organization of biomedical experiment, Measurement, 1999, 26, 19-44.
• [7] Walter E., Pronzato L: Qualitative and Quantitative Experiment Design for Phenomenological Models, Automatica, 1990, 26, 2, 195-213.