Introduction to mecanobiology of cells

• Autorzy: Stoltz J. F. , Wang X. , Muller S. , Labrador V.
• Konferencja: Proceedings of the International Conference on Engineering Rheology ICER '99
• Języki publikacji: EN

Abstrakty

EN

One fundamental property of living tissues is their ability of adaptation to environment because cells are always exposed to mechanical stresses related to environment or to movement (i.e. external pressure, blood flow pressure related to walking, ...). Today it's generally accepted that these mechanical forces can modify the biological behaviour of cells by affecting their metabolism, secretion of autocrin factors, phenotype, etc ... and that tissus can be remodelled by the mechanical environment. The modifications induced by mechanical factors are now considered as determinant to the comprehension of some patho-physiological processes (i.e.: atherosclerosis, thrombosis, arthrosis, inflammation, ...). In this work, we are going to demonstrate, through 3 examples of cells (cartilage chondrocyte, osteocyte and vascular endothelial cell), the importance of the mechanical factors in cell behaviour and the need of a better link between physics, mechanics and biology. Although numerous studies on this topics, the mechanisms of transduction from a mechanical signal to physiological responses or gene expression in cells remain unclear. In vitro studies on cultured cells allow us to have a good control of mechanical parameters and thus to understand better the induced modifications.

Słowa kluczowe

PL

biomechanika

• Wydawca: Oficyna Wydawnicza Uniwersytetu Zielonogórskiego
• Czasopismo: Applied Mechanics and Engineering
• Rocznik: 1999
• Tom: Vol. 4, no spec.
• Strony: 177--183
• Opis fizyczny: rys.

Twórcy

autor

Stoltz J. F.

autor

Wang X.

autor

Muller S.

autor

Labrador V.

• Angiohématologie - Hémorhéologie, UMR CNRS 7563 Faculté de Médecine, Brabois, BP 184, 54500 Vandouvre-les-Nancy, FRANCE