Rheological changes in rat blood as a result of photodynamic treatment

• Autorzy: Shulman Z. P. , Makhaniok A. A. , Vilanskaya S. V. , Zhavrid E. A. , Istomin Y. P. , Sheleg S. V.
• Konferencja: Second International Conference on Engineering Rheology ICER 2003
• Języki publikacji: EN

Abstrakty

EN

The purpose of this study was experimental investigation of hemorheological changes under photodynamic therapy. The experiments were conducted on laboratory white purebred male rats under narcosis. Chlorin e6 as photosensitizer (PS) was used. Photodynamic exposure (PDE) was performed with semiconductor laser (wave length 670nm). The irradiated area was , and light exposure dose E was 22.5 to . Blood was sampled 1 hour after PDE completion and was heparin-conserved. The experimental study of PDE effect on the rheological properties of blood of tumour-free rats revealed that chlorin at a dose of body mass caused a significant increase in the hematocrit H. The flow curves were adequately described by the power law rheological model with independent of H and E. The correction to the parameter of blood consistency K in rats not exposed to PDE assumed the form . The exposure of rat skin to light at E 22.5 to resulted in an increase in the consistency parameter. The flow curves taking into account PDE are adequately described by the model . The results obtained from this study indicate that PDE at a concentrated chlorin dose of and light exposure dose of 22.5 to produces a significant increase in rat blood non-newtonian viscosity.

Słowa kluczowe

EN

rheology; blood; plasma; photosensitizer; photodynamic therapy

PL

reologia; terapia fotodynamiczna; osocze

• Wydawca: Oficyna Wydawnicza Uniwersytetu Zielonogórskiego
• Czasopismo: International Journal of Applied Mechanics and Engineering
• Rocznik: 2003
• Tom: Vol. 8, no spec.
• Strony: 307--312
• Opis fizyczny: Bibliogr. 2 poz., tab., wykr.

Twórcy

autor

Shulman Z. P.

• Laboratory of Rheophysics and Macrokinetics A.V.Luikov Heat and Mass Transfer Institute, NAS, Minsk, BELARUS

autor

Makhaniok A. A.

• Laboratory of Rheophysics and Macrokinetics A.V.Luikov Heat and Mass Transfer Institute, NAS, Minsk, BELARUS

autor

Vilanskaya S. V.

• Laboratory of Rheophysics and Macrokinetics A.V.Luikov Heat and Mass Transfer Institute, NAS, Minsk, BELARUS

autor

Zhavrid E. A.

• Department of Chemotherapy, N.N. Alexandrov Research Institute of Oncology and Medical Radiology Minsk, BELARUS

autor

Istomin Y. P.

• Department of Chemotherapy, N.N. Alexandrov Research Institute of Oncology and Medical Radiology Minsk, BELARUS

autor

Sheleg S. V.

• Department of Chemotherapy, N.N. Alexandrov Research Institute of Oncology and Medical Radiology Minsk, BELARUS

Bibliografia

• [1] Dougherty T.J., Gomer Chr.J., Henderson B.W., Jori G., Kessel D„ Korbelik M„ Moan J. And Peng Q. (1WH)| Review: Photodynamic Therapy. - J. of the National Cancer Institute, vol.90, No. 12, pp.889-905.
• [2] Levtov V.A„ Regirer S.A. and Shadrina N.Kh. (1982): Blood Rheology. - Moscow: Medicine.