Development of a drug delivery system using microcapsules with ultrasound

• Autorzy: Masuda K.
• Języki publikacji: EN

Abstrakty

EN

Micrometer-sized microcapsules collapse upon exposure to ultrasound. Use of this pheno-menon for a drug delivery system (DOS), not only for local delivery of medication but also for gene therapy, should be possible. However, enhancing of efficiency of medication is limited because the capsules in suspension diffuse in the human body after injection, since the motion of the capsules in blood flow cannot be controlled. To control behavior of the microcapsules, an acoustic radiation force was introduced. We detected local changes in the microcapsule density by producing of acoustic radiation force in an artificial blood vessel. Furthermore, we theoretically estimated the conditions required for an active path selection of the capsules at a bifurcation point in the artificial blood vessel. We observed the difference in the capsule density at both in the bifurcation point and in alternative paths downstream of the bifurcation point for the different acoustic radiation forces. We also confirmed that the microcapsules are trapped against flow with the condition when the acoustic radiation force is more than the fluid resistance of the capsules. The possibility of controlling of the capsule flow towards a specific point in a blood vessel was demonstrated.

Słowa kluczowe

EN

microcapsule; acoustic radiation force; drug delivery; artificial blood vessel

PL

mikrokapsułka; podawanie leków; naczynie krwionośne

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2011
• Tom: Vol. 31, no. 2
• Strony: 23--32
• Opis fizyczny: Bibliogr. 15 poz., rys., wykr.

Twórcy

autor

Masuda K.

• Tokyo University of Agriculture & Technology, 2-24 Nakacho, Koganei, Tokyo, 184-8588 Japan,

Bibliografia

• 1. Watanabe M., Chihara K., Shirae K., Ishihara K., Kitabatake A.: Pressure Measurement Using Ultrasonic Resonance of Microcapsules. Jpn. J. Appl. Phys.1991, 30, 1, 241-243.
• 2. Okada K., Kudo N., Niwa K., Yamamoto K.: A basic study on sonoporation with microbubbles exposed to pulsed ultrasound. J. Med. Ultrason. 2005, 32, 3-11.
• 3. Koyama D., Osaki A., Kiyan W., Watanabe Y.: Optical Observation of Microcapsule Destruction in an Acoustic Standing Wave. IEEE Trans. Ultrason. Ferroelect. Freq. Control 2006, 53, 1314-1321.
• 4. Ishihara K., Yoshii K., Chihara K., Masuda K., Shirae K., Furukawa T.: Path Lines in Blood Flow using High-speed Digital Subtraction Echography. Proc. IEEE Ultrasonic Symp. 1992, 1277-1280.
• 5. Yamakoshi Y., Koshiba M., Ozawa Y., Masuda N.: Trapping of Micrometer Size Bubbles by Ultrasonic Waves. Jpn. J. Appl. Phys. 2001, 40, 1526-1527.
• 6. Wei K., Skyba D. M., Firschke C., Jayaweera A. R., Lindner K. R., Kaul S.: Interactions between micro-bubbles and ultrasound: in viteo and in vivo observations. J. Am. Coll. Cardiol. 1997, 9, 1081-1088.
• 7. Yoshikawa H., Azuma T., Sasaki K., Kawabata K., Umemura S.: Dynamic and Precise Visualization of Contrast Agent in Blood Vessels with Motion Correction. Jpn. J. Appl. Phys. 2006, 45, 4754-4760.
• 8. Mitome H.: Micro Bubble and Sonoluminescence. Jpn. J. Appl. Phys. 2001, 40, 3484-3487.
• 9. Yamakoshi Y., Miwa T.: Microbubble Self-Trapping to Surface of Target. Jpn. J. Appl. Phys. 2008, 47, 4127-4131.
• 10. Kozuka T., Yasui K., Tuziuti T., Towata A., Iida Y.: Acoustic Standing-Wave Field for Manipulation in Air. Jpn. J. Appl. Phys. 2008,47, 4336-4338.
• 11. Lilliehorn T., Simu U., Nilsson M., Almqvist M., Stepinski T., Laurell T., Nilsson J., Johansson S.: Trapping of microparticles in the near field of an ultrasonic transducer. Ultrasonics 2005, 43, 293-303.
• 12. Zheng H., Dayton P. A., Caskey C., Zhao S., Qin S., Ferrara K. W.: Ultrasound-Driven Microbubble Oscillation and Translation Within Small Phantom Vessels. Ultrasound in Medicine and Biology, 2007, 33, 1978-1987.
• 13. Hasegawa T., Kido T., Min C. W., Iizuka T., Matsuoka C.: Frequency dependence of the acoustic radiation pressure on a solid sphere in water. Acoust. Sci. Technol. 2001, 22, 273-282.
• 14. Masuda K., Muramatsu Y., Nakamoto R., Ueda S., Nakayashiki Y., Ishihara K.: Active Path Selection of Fluid Microcapsules in Artificial Blood Vessel by Acoustic Radiation Force. Jpn. J. Appl. Phys. 2009, 48, 7, 07GK03.
• 15. Muramatsu Y., Ueda S., Nakamoto R., Nakayashiki Y., Masuda K., Ishihara K.: Active path selection of fluid microcapsules by acoustic radiation force in the artificial blood vessel, Proc. 4th European Medical & Biological Engineering Conference 2008, 1589-1593.