Biventricular pacemaker synchronization: A numerical cardiocirculatory model application to reproduce in vivo data

• Autorzy: Di Molfetta A. , De Lazzari C. , Ferrari G. , Moscariello F. , Aguzzi G. , Fresiello L. , Darowski M. , Trivella M. G. , Alessandri N
• Języki publikacji: EN

Abstrakty

EN

Cardiac Resynchronization Therapy (CRT) seems to be the most encouraging treatment to limit the damages of ventricular remodelling in patients with moderate-severe cardiac insufficiency. Mathematical modelling of the cardiovascular system is a tool potentially useful to understand how the Biventricular Pacemaker (BPM) must be synchronised during CRT. In this work a computer simulator reproduces clinical data measured, on different patients affected by asynchronous ventricular contraction, before and after CRT. Three patients, affected by asynchronous ventricular contraction, were monitored before and after biventricular stimulation through CRT. Measured and simulated data were compared. Results show that the software simulator can well reproduce in vivo data. Besides, simulated results from BPM together with drug therapy are in accordance with literature data. Numerical modelling could be a useful tool to optimize the BPM synchronization.

Słowa kluczowe

EN

circulatory system; hemodynamics; coronary circulation; left ventricle; computer simulation

PL

układ krążenia; hemodynamika; krążenie wieńcowe; lewa komora; symulacja komputerowa

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2010
• Tom: Vol. 30, no. 1
• Strony: 3--15
• Opis fizyczny: Bibliogr. 14 poz., rys., tab., wykr.

Twórcy

autor

Di Molfetta A.

autor

De Lazzari C.

autor

Ferrari G.

autor

Moscariello F.

autor

Aguzzi G.

autor

Fresiello L.

autor

Darowski M.

autor

Trivella M. G.

autor

Alessandri N

• C.N.R., Institute of Clinical Physiology, U.O.S. of Rome, V.le dell'Universitá, 11, 00185 Rome, Italy,

Bibliografia

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