Interaction between left ventricle mechanics and myocardial blood flow

• Autorzy: Trivella M. G. , Pelosi G. , Neglia D. , L'Abbate A.
• Języki publikacji: EN

Abstrakty

EN

The interaction between coronary circulation and left ventricular mechanics has been studied in animal models as well as investigated in humans. Here we review the results of experimental studies performed at the Institute of Clinical Physiology: the separate contribution of preload and after load on coronary pressure-flow, pressure-volume and volume-flow relationships; single beat as well as averaged instantaneous loops, both during autoregulation and under maximal vasodilation. We then present the results of animal studies on estimate of functional microvascular architecture and its relationship with myocardial blood flow heterogeneity. Finally, we report on clinical applications performed in various models of left ventricular dysfunction as myocardial ischemia, hypertrophic cardiomyopathy, dilated cardiomyopathy and secondary hypertrophy, aimed at investigating the interaction between coronary flow and abnormal left ventricular mechanics.

Słowa kluczowe

EN

coronary circulation; left ventricular mechanics animal models; clinical studies

PL

krążenie wieńcowe; komora lewa; badania kliniczne

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2008
• Tom: Vol. 28, no. 1
• Strony: 3--16
• Opis fizyczny: Bibliogr. 11 poz., rys., wykr.

Twórcy

autor

Trivella M. G.

autor

Pelosi G.

autor

Neglia D.

autor

L'Abbate A.

• C.N.R. Institute of Clinical Physiology, Via Moruzzi n. 1, 56124 Pisa, Italy,

Bibliografia

• 1. Beyar R., Caminker R., Manor D., Sideman S.: Coronary flow patterns in normal and ischemic hearts: transmyocardial and artery to vein distribution. Ann. Biomed. Eng. 1993, 21, 4, 435-458.
• 2. Trivella M.G., Del Canizo J.F., Chieco S., Flameng W., Meli M., Meyns B., Monties J.R., Waldenberger F., Rakhorst G.: Guidelines for in-vivo testing of mechanical circulatory support systems. Report Concerted Action Heart Assist and Replacement, Section III - ISBN 88 - 86219.05.09, III-1- III-40, 1996.
• 3. L'Abbate A., Marzilli M., Ballestra A.M., Camici P., Trivella M.G., Pelosi G., Klassen G.A.: Opposite transmural gradients of coronary resistance and extravascular pressure in the working dog's heart. Cardiovascular. Res. 1980, 14, 21-29.
• 4. Bassingthwaighte J.B., King R.B., Roger S.A.: Fractal nature of regional myocardial blood flow heterogeneity. Circulation Research 1989, 65, 578-590.
• 5. Trivella M.G., Castellari M., Pelosi G., Barsotti G., Magnozzi D., Taddei L., Balocchi R., Marchesi C., L'Abbate A.: Microvascular perfusion unit visualized by computerized autoradiography of canine myocardium. Proceedings of Sixth World Congress for Microcirculation, Messmer K., Kubler W. M.(Eds), Monduzzi 1996, 851-855.
• 6. Pelosi G., Saviozzi G., Trivella M.G., L'Abbate A.: Transmural redistribution of coronary resistance during embolization: a clue to intramyocardial small artery architecture. Microvascular Research 1990, 39, 322-340.
• 7. Pelosi G., Saviozzi G., Trivella M.G., L'Abbate A.: Modeling of the intramyocardial canine microcirculation by small artery embolization. 6th World Congress for Microcirculation, K. Messmer, W. M. Kubler (Eds), Monduzzi 1996, 191-195.
• 8. Kassab G. S.: Scaling laws of vascular trees: of form and function. Am. J. Physiol. Heart Circ. Physiol. 2006, 290, H894-H903.
• 9. Trivella M.G., Castellari M., Pelosi G., Barsotti G., Magnozzi D., Taddei L., Balocchi R., Marchesi C., L'Abbate A.: Microvascular perfusion unit visualized by computerized autoradiography of canine myocardium. 6th World Congress for Microcirculation, K. Messmer, W. M. Kubler (Eds), Monduzzi 1996, 851-855.
• 10. Trivella M.G., Pelosi G.: Coronary Microcirculation. In: Textbook of Angiology, Chang J. B. (Ed), Springer-Verlag, New York, USA, 2000, 132-140.
• 11. Gimelli A., Schneider-Eicke J., Neglia D., Sambuceti G., Giorgetti A., Bigalli G., Parodi G., Pedrinelli R., Parodi O.: Homogeneously reduced versus regionally impaired myocardial blood flow in hypertensive patients: two different patterns of myocardial perfusion associated with degree of hypertrophy. J. Am. Coll. Cardiol. 1998, 31, 366-373.