Epithelial cell damage due to airway reopening – an experimental investigation

• Autorzy: Kuraszkiewicz B.
• Języki publikacji: EN

Abstrakty

EN

Airway collapse and reopening due to mechanical ventilation exerts mechanical stress on airway walls and injures surfactant - compromised lungs. The reopening of a collapsed airway was modeled experimentally by progression of a semi-infinite bubble in a narrow fluid-occluded channel. The extent of injury caused by bubble progression to pulmonary epithelial cells lining the channel was evaluated. Counter intuitively, cell damage increased with decreasing opening velocity. The presence of pulmonary surfactant, Infasurf, completely abated the injury. These results support the hypotheses that mechanical stresses associated with airway reopening injure pulmonary epithelial cells and that pulmonary surfactant protects the epithelium from this injury.

Słowa kluczowe

EN

pulmonary surfactant; acute respiratory distress syndrome; ventilator-induced lung injury

PL

surfaktant płucny; pulmonologia

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2007
• Tom: Vol. 27, no. 4
• Strony: 49--58
• Opis fizyczny: Bibliogr. 29 poz., rys., tab., wykr.

Twórcy

autor

Kuraszkiewicz B.

• Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Trojdena 4, 02-109 Warsaw, Poland,

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