Time-resolved reflectometry and spectroscopy for assessment of brain perfusion and oxygenation

• Autorzy: Liebert A. , Kacprzak M. , Maniewski R.
• Języki publikacji: EN

Abstrakty

EN

Time-resolved optical methods and instrumentation for non-invasive assessment of the cerebral cortex perfusion and oxygenation are presented. The oxygenation can be calculated using the moments of the distributions of times of flight of photons measured at two wavelengths in the near infrared region. For assessment of the brain perfusion, the kinetics of the inflow and washout of an exogenous dye injected intravenously is analyzed. The instrument developed at the Institute of Biocybernetics and Biomedical Engineering PAS is equipped with picosecond diode lasers, fast photodetectors and time correlated single photon counting electronics for acquisition of the distributions of times of flight of photons. This technique allows for a depth-resolved estimation of the changes of absorption and, in consequence, for an assessment of the changes occurring in the cerebral cortex. Combination of the data from multiple sources and detectors placed on the surface of the head with the depth-resolved analysis based on the moments enables to obtain images of the cortex perfusion and/or oxygenation. Potential applications of the instrument and its limitations are also discussed.

Słowa kluczowe

EN

near infrared spectroscopy; brain oxygenation; brain perfusion; time-resolved imaging

PL

spektroskopia podczerwona; dotlenienie mózgu

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2007
• Tom: Vol. 27, no. 1-2
• Strony: 217--225
• Opis fizyczny: Bibliogr. 24 poz., rys.

Twórcy

autor

Liebert A.

autor

Kacprzak M.

autor

Maniewski R.

• Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, 02-109 Warsaw, Trojdena 4 str., Poland,

Bibliografia

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