Development of implantable probe for observation of microcirculation

• Autorzy: Imachi K. , Mochizuki S. , Baba A. , Isoyama T. , Saito I. , Takiura K. , Chinzei T. , Shiraishi Y. , Yambe T. , Abe Y.
• Języki publikacji: EN

Abstrakty

EN

It is a long-term controversial point between the circulatory physiologists and the artificial heart researchers whether the pulsatile flow is essential for the living body or not [1]. In particular, since the axial flow pump, a continuous flow pump, that could keep the patients alive for more than a few years was introduced into use in clinical setting in 2001, this problem has been regarded as a very important physiological and pathophysiological issue. The objective of this study was to develop an implantable probe to observe microcirculation in artificial circulation. The principle of the probe developed in this study is the following: a thin living tissue is put directly on a highly integrated CCD (charge coupled device), and it is illuminated from the backside of the tissue with LED(light emitting diode). The microvascular nets in the tissue will be projected on the CCD surface, like a contact photograph, which produces an image on the TV screen. The problems are how to magnify them to be able to observe the erythrocyte flow, how to control the focus, how to electrically insulate them and how to make them compact. After several attempts to magnify the image, a micro lens having 2 mm in diameter, 2 mm long and 6 times magnification, was designed and made of acrylic resin. The lens was installed into a CCD camera with 8 mm in diameter and it was 60 mm long. The camera could magnify the image about 650 times on the 14 inches TV screen. A distinct microcirculation image, including the capillary flow, could be observed when the camera was implanted into the connective tissue under the skin of the rabbit. Now the focus control system is being developed with the camera to be implanted in animals on the long-term base.

Słowa kluczowe

EN

microcirculation; pulsatility; continuous flow; CCD (charge coupled devise); artificial heart

PL

mikrokrążenie; przepływ ciągły; sztuczne serce

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2007
• Tom: Vol. 27, no. 1-2
• Strony: 45--52
• Opis fizyczny: Bibliogr. 5 poz., fot., rys.

Twórcy

autor

Imachi K.

autor

Mochizuki S.

autor

Baba A.

autor

Isoyama T.

autor

Saito I.

autor

Takiura K.

autor

Chinzei T.

autor

Shiraishi Y.

autor

Yambe T.

autor

Abe Y.

• Tohoku University, 2-1 Seiryo-machi, Aoba, Sendai, Miyagi, 980-8575 Japan,

Bibliografia

• 1. Imachi K., Asano M., Fujimasa I., Sakurai Y., Atsumi K.: Micro-circulation in rabbit ear chamber during artificial heart pumping, Digest of 10th Intern. Conf. on Med. and Biolog. Eng., 1973, 137.
• 2. Imachi K., Chinzei T., Abe Y, Isoyama T., Mabuchi K., Imanishi K., Ono T., Kouno A., Kusakabe M., Atsumi K., Fujimasa I.: A new apparatus for chronic observation of microcirculation in-situ to evaluate an artificial organ performance. ASAIO Journal, 1994, 40(3), M757-761.
• 3. Imachi K., Abe Y, Chinzei T., Mabuchi K., Imanishi K., Isoyama T., Kouno A., Ono T., Fujimasa I.: Factors Influencing hemodynamics blood chemical data and hormone secretion of total artificial heart goat. In: Progress in Microcirculation Research, H. Niimi, M. Oda, T. Sawada, R-J Xiu (Eds), Pergamon Press, London, 1994,453-458.
• 4. Imachi K., Chinzei T., Abe Y., Isoyama T., Mabuchi K., Imanishi K., Ono T., Kouno A., Kusakabe M., Onuma M., Atsumi K., Fujimasa I.: Development of a new apparatus to observe the microcirculation chronically in a continuous flow blood pump research. Artificial Organs, 1995,19(7), 723-728.
• 5. Imachi K., Chinzei T., Abe Y, Isoyama T., Mabuchi K., Imanishi K., Kusakabe M., Ohnuma M., Fujimasa I.: A new method for the chronic evaluation of the microcirculation during artificial heart pumping. In Heart Replacement-Artificial Heart 5, T. Akutsu, H. Koyanagi (Eds), Springer-Verlag, Tokyo, 1996, 281-287.