Optimal inputs in pharmacokinetics model's identification

• Autorzy: Pietrenko-Dąbrowska A. , Kalicka R.
• Języki publikacji: EN

Abstrakty

EN

The paper presents optimal input design for parametric identification of the SISO state space compartmental models of pharmacokinetic systems. The adopted objective function is the trace of the Fisher information matrix (the sensitivity criterion). The class of equienergy admissible inputs is concemed, as rate-dependent side effects occur for many medicines. The optimal input design problem is a nonlinear programming problem with constraint. The problem is solved using Kuhn-Tucker necessary conditions. SeveraI compartmental models were examined. The optimal inputs of different shapes were obtained and compared.

Słowa kluczowe

EN

optimal input design; compartmental models; parameter estimation

PL

farmakokinetyka; estymacja parametrów; medycyna

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2006
• Tom: Vol. 26, no. 3
• Strony: 3--14
• Opis fizyczny: Bibliogr. 17 poz., rys., tab., wykr.

Twórcy

autor

Pietrenko-Dąbrowska A.

autor

Kalicka R.

• Faculty of Electronics, Telecommunication and Informatics, Gdańsk University of Technology, 80-952 Gdańsk, Narutowicza 11/12, Poland,

Bibliografia

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