Significance of the neuronal morphology for network dynamics

• Autorzy: Meyrand P.
• Języki publikacji: EN

Abstrakty

EN

One of the striking features of the Nervous System is the complexity and diversity of the neuronal shapes. Extensive morphological studies associated with modeling approaches have emphasized a close relationship between the neuron structure and its bioelectrical properties. However, structural implications of the synaptic connectivity (spatial distribution, number of synapses) in the context of the network operation are far less studied. To explore this issue, the chemical inhibitory synapses between identified motoneurones belonging to the stomatogastric nervous system of the lobster Homarus gammarus were examined. Using multiple intracelIular dyes injected in both pre- and post synaptic motoneurones, the sites of the appositions between these two celIs were localized under the laser-scanning confocal microscopy, and then the synaptic release sites were visualized under the electron microscopy. Such analysis indicates that only one or two zones of apposition exist between the two celIs studied, and only one release site exists per zone. Moreover, these synaptic sites are always located in the same position within the dendritic arbor. Modeling studies suggest that such a specific localization may play an important role in the operation of the network.

Słowa kluczowe

EN

nervous system; neuronal networks; motoneuron; rhythmic activity; chemical inhibitory synapses

PL

system nerwowy; sieć neuronowa; neuron ruchowy

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2006
• Tom: Vol. 26, no. 2
• Strony: 15--23
• Opis fizyczny: Bibliogr. 8 poz., rys.

Twórcy

autor

Meyrand P.

• Laboratoire de Neurobiologie des Reseaux, CNRS UMR 5816 et Universite Bordeaux l, Avenue des Facultes, 33400 Talence, France,

Bibliografia

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• 2. Cabirol-Pol M.J., Combes D., Fenelon V.S., Simmers J., Meyrand P.: Rare and spatially segregated release sites mediate a synaptic interaction between two identified network neurons. J. Neurobiol. 2002, 50, 2, 150-163.
• 3. Fabian-Fine R., Volknandt W., Seyfarth E.-A.: Peripheral synapses at identifiable mechanosensory neurons in the spider Cupiennius salei: synapsin-like immunoreactivity. Cell Tissue Res. 1999, 295, 13-19.
• 4. Harris-Warrick R.M., Marder E., Selverston A.I., Moulins M.: Dynamic biological networks: The stomatogastric nervous system. Cambridge, MA :MIT Press 1999.
• 5. Korogod S.M., Kopysova I.L., Bras H., Gogan P., Tyc-Dumont S.: Differential back-invasion of a single complex dendrite of an abducens motoneuron by N-methyl-D-aspartate-induced oscillations: a simulation study. Neuroscience. 1996, 75, 4, 1153-1163.
• 6. Le Feuvre Y., Fenelon V.S., Meyrand P.: Ontogeny of modulatory inputs to motor networks: early established projection and progressive neurotransmitter acquisition. J. Neurosci. 2001, 15, 21, 4, 1313-1326.
• 7. Moulins M., Cournil I.: All-or-none control of the bursting properties of the pacemaker neurons of the lobster pyloric pattern generator. J. Neurobiol. 1982, 13, 447-458.
• 8. Ramon y Cajal S.: Histologie du Système Nerveux de l'homme et des vertébrés. Maloine; Paris, France 1911.