Simulating niflumic acid effect on sinoatrial node cells

• Autorzy: Cieniawa J.
• Języki publikacji: EN

Abstrakty

EN

It was recently reported that niflumic acid was capable of inhibiting the hyperpolarization-activated pacemaker current. To obtain insights into the ionic mechanisms governing niclumic acid effect on cardiac sinoatrial (SA) myocytes, computer simulations were performed based on a computer model of electrical activity of SA node cells. One cell was described by 15 nonlinear first-order differential equations that describe the time course of transmembrane potential difference, ionic concentrations, and states of the voltage gated ionic channels. The inhibition of the hyperpolarization-activated pacemaker current contributed to the chronotropic effect by reducing the rate of diastolic depolarization.

Słowa kluczowe

EN

pacemaker current; sinoatrial; chronotropic effect; mathematical model

PL

stymulator prądu; węzeł zatokowo-przedsionkowy; model matematyczny

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2004
• Tom: Vol. 24, no. 3
• Strony: 61--65
• Opis fizyczny: Bibliogr. 10 poz., wykr.

Twórcy

autor

Cieniawa J.

• Medical University of Lublin, Departament of Biophysics, al. Racławickie 1, 20-059 Lublin, Poland,

Bibliografia

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