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It was recently reported that niflumic acid was capable of inhibiting the hyperpolarization-activated pacemaker current. To obtain insights into the ionic mechanisms governing niclumic acid effect on cardiac sinoatrial (SA) myocytes, computer simulations were performed based on a computer model of electrical activity of SA node cells. One cell was described by 15 nonlinear first-order differential equations that describe the time course of transmembrane potential difference, ionic concentrations, and states of the voltage gated ionic channels. The inhibition of the hyperpolarization-activated pacemaker current contributed to the chronotropic effect by reducing the rate of diastolic depolarization.
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Tom
Strony
61--65
Opis fizyczny
Bibliogr. 10 poz., wykr.
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autor
- Medical University of Lublin, Departament of Biophysics, al. Racławickie 1, 20-059 Lublin, Poland, cieniawa@panaceum.am.lublin.pl
Bibliografia
- [1] Boyett M.R., Honjo H., Kodama I.: The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc. Res. 2000,47, 658-687.
- [2] Irisawa H, Brown H.F., Giles W.: Cardiac pacemaking in the sino-atrial node. Physiol. Rev. 73 197-227
- [3] Accili E. A. DiFrancesco D.: Inhibition of the hyperpolarization-activated current (if) of rabbit SA node myocytes by niflumic acid. Pflugers Arch. - Eur. J. Physiol. 1996, 431, 757-762.
- [4] Baker A., Northrop F.D., Miedema H„ Devine G.R., Davies J.M, The non-steroidal anti-inflammatory drug niflumic acid inhibits Candida albicans growth. Mycopathologia 2002, 153, 25 8.
- [5] Gadad A.K., Bhat S, Tegeli V.S., Redasani V.V.: Synthesis, spectral studies and anti-inflammatory activity of glycolamide esters of niflumic acid as potential prodrugs. Arzneimittelforschung 2002, 52, 817-821.
- [6] Demir S.S., Clark J.W., Murphey C.R., Giles W.R.: A mathematical model of a rabbit sinoatrial node cell. Am. J. Physiol. 1994, 266, C832-C852.
- [7] Dokos S, Celler B, Lovell N.: Vagal control of sinoatnal rhythm: a mathematical model. J. Theor. Biol 1996, 182, 21-44.
- [8] Michaels D.C., Matyas E.P., Jalife J.: A mathematical model of the effects of acetylcholine pulses on sinoatrial pacemaker activity. Circ. Res. 1984, 55, 89-101.
- [9] Wilders R. Jongsma H.J., van Ginneken A.C.G.: Pacemaker activity of the rabbit sinoatrial node. A comparison of mathematical models. Biophys. J. 1991, 60, 1202-1216.
- [10] Satoh T„ Yamada M.: Niflumic acid reduces the hyperpolarization-activated current (1(h)) in rod photoreceptor cells. Neurosci. Res. 2001, 40, 375-381.
Typ dokumentu
Bibliografia
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bwmeta1.element.baztech-article-BPZ1-0011-0018