A new achievement in obtaining durable antibacterial protection for vascular prostheses

• Autorzy: Ginalska G. , Osińska M. , Urbaniak-Sypniewska T. , Uryniak A. , Łobarzewski J.
• Języki publikacji: EN

Abstrakty

EN

Gentamicin covalently bound to bead shaped silica supports or Tricogel (vascular prosthesis) demonstrates stability for even up to 30 days. A comparison was made of the results of gentamicin immobilization to silica supports or Tricogel pieces activated in two modes. Gentamicin retention (during a 30-day experiment) on the Tricogel was shown to be higher than that on silica supports. The release of gentamicin from four matrices was observed only during the first 4 days of the 30-day experiments. The biological activity of gentamicin against "Escherichia coli", "Pseudomonas aeruginosa" and "Staphylococcus aureus" was also checked. In these experiments we used samples of Tricogel irradiated in UV (control), soaked in gentamicin solution or containing gentamicin covalently bound to this matrix. The covalently bound gentamicin was shown to inhibit completely the growth of all the three bacterial strains during the experiment.

Słowa kluczowe

EN

gentamicin; covalent immobilization; silica supports; vascular prostheses

PL

gentamycyna; nośnik krzemionkowy; proteza naczyniowa

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2004
• Tom: Vol. 24, no. 1
• Strony: 17--24
• Opis fizyczny: Bibliogr. 24 poz., tab., wykr.

Twórcy

autor

Ginalska G.

• Departament of Biochemistry, Maria Curie-Skłodowska University, 20-031 Lublin, Poland

autor

Osińska M.

• Departament of Biochemistry, Maria Curie-Skłodowska University, 20-031 Lublin, Poland

autor

Urbaniak-Sypniewska T.

• Departament of General Microbiology, Maria Curie-Skłodowska University, Lublin, Poland

autor

Uryniak A.

• Division of General and Vascular Surgery, Municipal Hospital, Rzeszów, Poland

autor

Łobarzewski J.

• Departament of Biochemistry, Maria Curie-Skłodowska University, 20-031 Lublin, Poland

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