Single nucleotide polymorphisms applied in statistical inference of population growth

• Autorzy: Polański A. , Starosolski Z. , Świerniak A. , Kimmel M.
• Języki publikacji: EN

Abstrakty

EN

We have evaluated probability distributions of estimates of parameters of population growth, based on data on frequencies of alleles of unlinked SNP sites in DNA, modeled with the use of time dependent coalescence process acting together with mutation of a very low intensity. Probability distributions of maximum likelihood estimates of the product parameter of the present population effective size and exponent coefficient, for exponential scenario, have atoms at zero and long tails to the right. For stepwise scenario, log likelihood functions typically exhibit very long lines, covering many decades of the scale, of almost the same value of log likelihood. Observational data from [14] are consistent with the hypothesis of the population growth.

Słowa kluczowe

EN

single nucleotide polymorphisms; coalescence; demography

PL

pojedyncze nukleotydowe polymorfizmy; koalescencja; demografia

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2003
• Tom: Vol. 23, no. 4
• Strony: 45--61
• Opis fizyczny: Bibliogr. 30 poz., rys., tab., wykr.

Twórcy

autor

Polański A.

• Departament of Statistics, Rice University, Houston, TX, USA; Institute of Automatic Control, Silesian Technical University, Gliwice, Poland

autor

Starosolski Z.

• Institute of Automatic Control, Silesian Technical University, Gliwice, Poland

autor

Świerniak A.

• Institute of Automatic Control, Silesian Technical University, Gliwice, Poland

autor

Kimmel M.

• Departament of Statistics, Rice University, Houston, TX, USA

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