PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
Tytuł artykułu

Dynamic surface tension as an indicator of lung function in health and disease

Autorzy
Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The paper summarizes recent achievements in the using the techniques of determination of dynamic surface tension for the evaluation of quality of the pulmonary surfactant (PS). Based on the essential information on physical chemistry of the PS system, the importance of the dynamic surface activity of the surfactant for physiological functions of the lungs is demonstrated and the experimental methods for studying those properties in vitro are presented. Several examples of applications of dynamic tensiometry for assessment the PS functions are shown, including the research on toxicity of inhaled air polutants, approach to diagnosis the pulmonary diseases and interactions with PFCs used in partial liquid ventilation. The perspectives of future applications of physicochemical methods in pulmonary surfactant research (e.g., development of surfactant supplementation therapy) are suggested.
Twórcy
Bibliografia
  • [1] Keough K.M.W.: Physical chemistry of pulmonary surfactant in the terminal air spaces. In: B. Robertson, L.M.G. Van Golde, J.J. Batenburg, eds. Pulmonary Surfactant: From Molecular Biology to Clinical Practice. Elsevier, Amsterdam, 1992, 109.
  • [2] Goerke J.: Surfactant and lung mechanics, ibid.: 164.
  • [3] Walters D.V.: The role of the pulmonary surfactant in transepithelial movement of liquid, ibid.: 193.
  • [4] Van Iwaarden J. F.: Surfactant and the pulmonary defense system, ibid.: 215.
  • [5] Gehr P., Green F. H. Y., Geiser M., Im Hof V., Lee M. M., Schiirch S.: Airway surfactant, a primary defense barrier: mechanical and immunological aspects. J. Aerosol Med. 1996, 9, 163.
  • [6] Podgórski A., Gradoń L.: Dynamics of pulmonary surfactant and its role in alveolar cleansing. Ann. Occup. Hyg. 1990, 34, 137.
  • [7] Sosnowski T. R.: Sorption induced Marangoni microflows in the pulmonary surfactant system. Inż. Chem. Proces. 2001, 22, 251.
  • [8] Sosnowski T. R., Gradoń L., Skoczek M., Droździel H.: Experimental evaluation of importance of the pulmonary surfactant for oxygen transfer rate in human lungs. Int. J. Occup. Safety Ergon. 1998, 4, 391.
  • [9] Robertson B.: Animal models of neonatal surfactant dysfunction. In: B. Robertson, L. M. G. Van Golde, J. J. Batenburg, eds. Pulmonary Surfactant: From Molecular Biology to Clinical Practice. Elsevier, Amsterdan 1992, 459.
  • [10] Holm B. A.: Surfactant inactivation in adult respiratory distress syndrome ibid.: 665.
  • [11] Sosnowski T. R., Podgórski A.: Assesment of the pulmonary toxicity of inhaled gases and particles with physicochemical methods. Int. J. Occup. Safety Ergon 1999, 5, 433.
  • [12] Hildebran J. N., Goerke J., Clements J. A.: Pulmonary surface film stability and composition. J. Appl. Physiol. 1979, 47, 604.
  • [13] Gradoń L., Podgórski A., Sosnowski T. R.: Experimental and theoretical investigations of transport properties of DPPC monolayer. J. Aerosol Med. 1996, 9, 357.
  • [14] Notter R. H., Taubold R., Mavis R. D.: Hysteresis in saturated phospholipid and its potential relevance in vivo. Exp. Lung Res. 1982, 3, 109.
  • [15] Sosnowski T. R.: How to evaluate the pulmonary surfactant quality with the oscilating bubble technique. Proc. Dept. Chem. Eng. (Warsaw) 2000, 26, 97.
  • [16] Podgórski A., Sosnowski T. R., Gradoń L.: Effect of acidic environmental aerosols on the pulmonary surfactant activity: experimental studies. J Aerosol Sci., 30S1, S705.
  • [17] Podgórski A., Sosnowski T. R., Gradoń L.: Deactivation of the pulmonary surfactant dynamics by toxic aerosols and gases. J. Aerosol Med. 2001, 14, 455.
  • [18] Finlayson-Pitts B. J. et. al.: Are changes in breathing pattern on exposure to ozone related to changes in pulmonary surfactant? Inhal. Toxicol. 1994, 6, 267.
  • [19] Schlesinger R. B.: Functional assessment of rabbit AM following intermittent inhalation exposures to sulfuric acid mist. Fundam. Appl, Toxicol., 1987, 8, 328.
  • [20] Jugg B., Jenner J., Rice P.: The effect of perfluoroisobutene and phosgene on rat lavage fluid surfactant phospholipids. Hum. Exp. Toxicol. 1999, 18, 659.
  • [21] Sosnowski T. R., Gradoń L., Podgórski A.: Influence of insoluble aerosol deposits on the surface activity of the pulmonary surfactant: a possible mechanism of alveolar clearance retardation? Aerosol Sci. Techn. 2000, 32, 52.
  • [22] Morrow P. E.: Dust overloading of the lungs: update and appraisal. Toxicol. Appl. Pharmacol. 1992, 113,1.
  • [23] Sosnowski T. R., Gradoń L., Podgórski A., Wróbel J., Pirożyński M.: Discussion of application of PBS bubble tensiometer in diagnostics of pulmonary diseases. Proceedings of XVI Natl. Conf. of Chem. Proc. Engng., Kraków, Sept. 22-25, 1998, Vol. IV: 293 (in Polish).
  • [24] Leach C. L., Greenspan J. S., Rubenstein S. D.: Partial liquid ventilation with perflurbron in premature infants with severe respiratory distress syndrome. N. Engl. J. Med. 1996, 335, 761.
  • [25] Sosnowski T. R., Gradoń L., Podgórski A.: Nebulization of pulmonary surfactant formulations. J. Aerosol Med. 1999, 12, 123.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPZ1-0003-0052
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.