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Dynamics of the Tumor-Immune System Competition-the Effect of Time Delay

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Języki publikacji
EN
Abstrakty
EN
The model analyzed in this paper is based on the model set forth by V.A. Kuznetsov and M.A. Taylor, which describes a competition between the tumor and immune cells. Kuznetsov and Taylor assumed that tumor-immune interactions can be described by a Michaelis-Menten function. In the present paper a simplified version of the Kuznetsov-Taylor model (where immune reactions are described by a bilinear term) is studied. On the other hand, the effect of time delay is taken into account in order to achieve a better compatibility with reality.
Rocznik
Strony
395--406
Opis fizyczny
Bibliogr. 14 poz., tab., wykr.
Twórcy
autor
  • Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, ul. Trojdena 4, 02-109 Warsaw, Poland, magda@ibib.waw.pl
Bibliografia
  • [1] Bodnar M. (2000): The nonnegativity of solutions of delay differential equations. — Appl. Math. Lett., Vol. 13, No. 6, pp. 91–95.
  • [2] Bodnar M. and Foryś U. (2000a): Behaviour of solutions to Marchuk’s model depending on a time delay. — Int. J. Appl. Math. Comput. Sci., Vol. 10, No. 1, pp. 97–112.
  • [3] Bodnar M. and Foryś U. (2000b): Periodic dynamics in the model of immune system. — Appl. Math., Vol. 27, No. 1, pp. 113–126.
  • [4] Byrne H.M. (1997): The effect of time delay on the dynamics of avascular tumour growth. — Math. Biosci., Vol. 144, No. 2, pp. 83–117.
  • [5] Foryś U. (2002): Marchuk’s model of immune system dynamics with application to tumour growth. — J. Theor. Med., Vol. 4, No. 1, pp. 85–93.
  • [6] Foryś U. and Kolev M. (2002): Time delays in proliferation and apoptosis for solid avascular tumour. — Prep. Institute of Applied Mathematics and Mechanics, No. RW 02–10 (110), Warsaw University.
  • [7] Foryś U. and Marciniak-Czochra A. (2002): Delay logistic equation with diffusion.—Proc. 8-th Nat. Conf. Application of Mathematics in Biology and Medicine, Lajs, pp. 37–42.
  • [8] Hale J.K. (1997): Theory of functional differential equations — New York: Springer.
  • [9] Kirschner D. and Panetta J.C. (1998): Modeling immunotherapy of the tumor—immune interaction — J. Math. Biol., Vol. 37, No. 3, pp. 235–252.
  • [10] Kuang Y. (1993): Delay Differerntial Equations with Applications in Population Dynamics—London: Academic Press.
  • [11] Kuznetsov V.A. and Taylor M.A. (1994): Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis. — Bull. Math. Biol., Vol. 56, No. 2, pp. 295–321.
  • [12] Mayer H., Zänker K.S. and der Heiden U. (1995) A basic mathematical model of the immune response. — Chaos, Vol. 5, No. 1, pp. 155–161.
  • [13] Perko L. (1991): Differential Equations and Dynamical Systems —New York: Springer.
  • [14] Waniewski J. and Zhivkov P. (2002): A simple mathematical model for tumour-immune system interactions. — Proc. 8-th Nat. Conf. Application of Mathematics in Biology and Medicine, LAjs, pp. 149–154.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPZ1-0002-0036
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