Synthesizing cysteine-coated magnetite nanoparticles as MRI contrast agent: Effect of pH and cysteine addition on particles size distribution

• Autorzy: Ahmadi R. , Ranjbarnodeh E. , Gu N.
• Języki publikacji: EN

Abstrakty

EN

Cysteine capped magnetite nanoparticles (10 to 20 nm) were synthesized via coprecipitation method under ultrasonic irradiation. The influence of pH value of the solution and cysteine addition on the size distribution and hydrodynamic size of nanoparticles were studied via TEM and PCS methods, respectively. The crystal structure and magnetic properties of the nanoparticles were characterized by XRD and VSM techniques, respectively. Coating density was calculated using TGA and TEM results. Cytotoxicity assessment performed by incubation of L929 cells, confirmed that ferrofiuids are biocompatible. MRI studies conducted on rats demonstrated suitability of synthesized nanoparticles as contrast agents, especially for imaging of the lymph nodes.

Słowa kluczowe

EN

coprecipitation; nanoparticles; electron microscopy; biocompatibility

• Wydawca: De Gruyter
• Czasopismo: Materials Science Poland
• Rocznik: 2012
• Tom: Vol. 30, No. 4
• Strony: 382--389
• Opis fizyczny: Bibliogr. 21 poz., rys.

Twórcy

autor

Ahmadi R.

autor

Ranjbarnodeh E.

autor

Gu N.

• Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran

Bibliografia

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