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Biocomposites with submicrocrystalline sintered corundum and bioglass system as substrates and their structural and physical properties. Short- and long-term cultures of the fibroblast human skin on these substrates

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The results of studies of the effects of the process for obtaining biocomposites containing alumina submicrocrystalline sintered corundum grains as a matrix and a bioglass CaO-SiO2-P2O5-Na2O system as a bound phase on its microstructure and biocompatibility are presented. Microscopic observation was carried out on samples (SEM), the real, an apparent, helium density, total porosity, surface area, SBET, volume and percentage of macro- and mesopores, the biocomposites surface roughness parameters (Ra, Rz, Rt, profile material ratio Rmr, linear bearing part, amplitude distribution of the ordinate) were determined. It has been found that with the increase in glass system content, the density of biocomposite is decreasing. Biocompatibility was determined by the degree of growth of a human skin fibroblast cell line CCL 110 cultured on these substrates for 96 and 360 hours. The best results for maintaining short-term (96 h) culture were obtained on the substrate without densification with 10 wt% admixture of a bioglass system.
Czasopismo
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Strony
387--397
Opis fizyczny
Bibliogr. 12 poz.
Twórcy
autor
autor
autor
autor
autor
  • The Institute of Advanced Manufacturing Technology, Wrocławska 37A, 30-011 Kraków, Poland
Bibliografia
  • [1] SHI D., Biomaterials and Tissue Engineering, Springer-Verlag, Berlin, 2004.
  • [2] BROVARONE C., VERNE E., APPENDINO P., Macroporous bioactive glass-ceramic scaffolds for tissue engineering, Journal of Materials Science: Materials in Medicine 17(11), 2006, pp. 1069–1078.
  • [3] SACHLOS E., CZERNUSZKA J.T., Making tissue engineering scaffolds work. Review: The application of solid freeform fabrication technology to the production of tissue engineering scaffolds, European Cells and Materials 5, 2003, pp. 29–40.
  • [4] BŁAŻEWICZ S., STOCH L., Biomateriały, Vol. 4. Akademicka Oficyna Wydawnicza Exit, Warszawa,2003, (in Polish).
  • [5] JAEGERMANN Z, ŚLÓSARCZYK A., Gęsta i porowata bioceramika korundowa w zastosowaniach medycznych, Uczelniane Wydawnictwo Naukowo-Dydaktyczne AGH, Kraków, 2007, (in Polish).
  • [6] NIŻANKOWSKI CZ., Manufacturing sintered corundum abradants, Archives of Civil and Mechanical Engineering 2, 2002, pp. 53–64.
  • [7] SZARSKA S., STANIEWICZ-BRUDNIK B., LEKKA M., The effect of the size of the substrate grain made of submicrocrystalline sintered corundum on the bioglass composite structure and certain physico--mechanical properties of the bioglass, Optica Applicata 38(1), 2008, pp. 251–258 .
  • [8] JAEGERMANN Z., MICHAŁOWSKI S., KARAŚ J., CHROŚCICKA A., LEWANDOWSKA-SZUMIEŁ M., Porowate nośniki korundowe do zastosowania w inżynierii tkankowej, Szkło i Ceramika, No. 4, 2006,pp. 16–20,
  • [9] PUTTINI S., LEKKA M., DORCHIES O.M., SAUGY D., INCITTI T., RUEGG U.T., BOZZONI I., KULIK A.J., MERMOD N., Gene-mediated restoration of normal myofiber elasticity in dystrophic muscles, Molecular Therapy 17(1), 2008, pp. 19–25.
  • [10] ŚLÓSARCZYK A., RAPACZ-KMITA A., Bioaktywne ceramiczne materiały kompozytowe, Materiały Ogniotrwałe, Polskie Towarzystwo Ceramiczne, Kraków, 2004, (in Polish).
  • [11] STANIEWICZ-BRUDNIK B., LEKKA M., JAWORSKA L., WILK W., Biocompatible glass composite system – some physical-mechanical properties of the glass composite matrix system, Optica Applicata 40(2), 2010, pp. 403–412.
  • [12] STANIEWICZ-BRUDNIK B., LEKKA M., BĄCZEK E., WODNICKA K., WILK W., The effect of the method of obtaining the submicrocrystalline sintered corundum-bioglass composite matrix system on its microstructure and biocompatibility, Monograph The Faculty of Mechanical Engineering Łódź University of Technology, Łódź, Poland, 2010, pp. 71–80.
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPW7-0023-0024
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