Spectroscopic properties of a chlorophyll-based photosensitive dye entrapped in sol-gel fibre-optic applicators

• Autorzy: Ulatowska-Jarża A. , Bindig U. , Podbielska H. , Hołowacz I. , Stręk W. , Müller G. , Eichler H. J.
• Konferencja: Sol-Gel Materials Research, Technology, Applications SGM'04, 6-11 june 2004
• Języki publikacji: EN

Abstrakty

EN

One of the promising modalities of modern medical treatment is interstitial laser therapy, where a special fibre-optic applicator is used to ensure a proper curing light distribution in the pathological lesion. Such an applicator can act as a light diffuser, and simultaneously it can serve as a carrier of the therapeutic medium, e.g. a photosensitive dye for photodynamic therapy in situ. For applicator construction, silica based sol-gels coatings are proposed in this paper. The sol-gel applicators were prepared from the silicate precursor TEOS (tetraethylorthosilicate) mixed with ethyl alcohol in acid-catalysed hydrolysis. A suitable amount of surfactant (Triton X-100) was used. The carrier matrices were produced with a solvent to precursor molar ratio of 20. In these studies, optical fibres from Laser Components were used (core diameter 400 nm, HCS, low OH). The external jacket was mechanically removed at a distance of 25 mm. The modified dip-coating method was exploited to cover the bare fibres with sol-gel material. Two types of applicators were produced, silica sol-gels with an addition of chlorophyll-derived sensibilisator (Photolon) in two various concentrations. It was proved that the immobilization of Photolon in a silica sol-gel does not destroy its chemical activity and does not disturb contact with the external environment.

Słowa kluczowe

EN

sol-gel coatings; fibre optic applicator; chlorophyll-based photosensitiser

• Wydawca: De Gruyter
• Czasopismo: Materials Science Poland
• Rocznik: 2005
• Tom: Vol. 23, No. 1
• Strony: 111--122
• Opis fizyczny: Bibliogr. 18 poz.

Twórcy

autor

Ulatowska-Jarża A.

• Bio-Optics Group, Institute of Physics, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland

autor

Bindig U.

• Laser-und Medizin-Technologie GmbH, Berlin, Germany

autor

Podbielska H.

• Bio-Optics Group, Institute of Physics, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland
• Institute of Optics, Technical University Berlin, Berlin, Germany

autor

Hołowacz I.

• Bio-Optics Group, Institute of Physics, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland

autor

Stręk W.

• Institute of Low Temperature and Structure Research, Polish Academy of Science, Wroclaw, Poland

autor

Müller G.

• Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Institute of Laser Physics and Laser Medicine, Freie University Berlin, Berlin, Germany

autor

Eichler H. J.

• Laser-und Medizin-Technologie GmbH, Berlin, Germany
• Institute of Optics, Technical University Berlin, Berlin, Germany

Bibliografia

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