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A new generation of photosensitizers for photodynamic therapy (PDT) has been investigated. Different amino acids were bound to protoporphyrin (PP). Two methods of determination the quantum yield of generated singlet oxygen in porphyrin solutions were investigated. In the first method, tryptophan was used as a singlet oxygen acceptor. In the second one, the amount of singlet oxygen was determined by phosphorescence at 1272 nm. The purpose of this work was to evaluate the quantum yield of singlet oxygen of different PP(AA)2Arg2 derivatives, since it is crucial for choosing proper ingredients of photosensitizer for diagnosis and therapy in PDT
Słowa kluczowe
Czasopismo
Rocznik
Tom
Strony
505--519
Opis fizyczny
Bibliogr. 9 poz., rys., tab.
Twórcy
autor
- Institute of Optoelectronics, Military University of Technology, ul. Stefana Kaliskiego 2, 00-908 Warszawa, Poland
autor
- Institute of Optoelectronics, Military University of Technology, ul. Stefana Kaliskiego 2, 00-908 Warszawa, Poland
autor
- Institute of Optoelectronics, Military University of Technology, ul. Stefana Kaliskiego 2, 00-908 Warszawa, Poland
autor
- Institute of Optoelectronics, Military University of Technology, ul. Stefana Kaliskiego 2, 00-908 Warszawa, Poland
Bibliografia
- [1] Shu Ye., Czuba M., Romiszewska A., Karolczak J., Graczyk A., Opt. Appl. 33 (2003), 489.
- [2] Turro N.J., Singlet oxygen and chemiluminescent organic reactions, Modem Molecular Photochemistry, University Science Books, California 1991, pp. 583-593.
- [3] Foote C.S., Mechanisms of photo-oxygenation, [In] Porphyrin Localization and Treatment of Tumors, [Eds.] D.R. Doiron, C.J. Gomer, Alan R. Liss, New York 1984, pp. 3-18.
- [4] Wilkinson F., Helman W., Ross A., J. Phys. Chem. Ref. Data 22 (1993) 113.
- [5] Padzik-Graczyk A., Konarski J., Sobczyńska J., Method of hemins synthesis, PL 165248B1/94 (1994), (in Polish).
- [6] Graczyk A., Konarski J., Complex Salts Hematoporphyrin and its derivatives, their synthesis and Therapeutic Agents, US 005451599A , 1995; EP0539960A2/97, 1997.
- [7] LambertC.R., Reddi E., SpikesJ.D., RodgersM.A.J.,Jori G., Photochem. Photobiol. 44(1986), 595.
- [8] Reddi E., Rodgers M.A.J., Spikes J.D., Jori G., Photochem. Photobiol. 40 (1984), 415.
- [9] Rodgers M.A., Snowden P.T., J. Am. Chem. Soc. 104 (1982), 5541.
Typ dokumentu
Bibliografia
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bwmeta1.element.baztech-article-BPW1-0014-0036