Application of principal component and factor analysis of fluorescence spectra in camptothecin studies

• Autorzy: Kruszewski S. , Siuda R. , Ziomkowska B. , Cyrankiewicz M.
• Języki publikacji: EN

Abstrakty

EN

The application of fluorescence spectroscopy methods in investigations of camptothecin (CPT) is presented in this paper. Fluorescence of CPT enables one to follow the process of hydrolysis, i.e., the process of converting the biologically active lactone form into inactive carboxylate. The fluorescence spectra of CPT recorded during the hydrolysis were analysed using principal component analysis (PCA) and factor analysis (FA). The results obtained on the basis of fluorescence spectra analysis are compared with high performance liquid chromatography (HPLC) data.

Słowa kluczowe

EN

camptothecin; fluorescence; principal component analysis; factor analysis

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Optica Applicata
• Rocznik: 2003
• Tom: Vol. 33, nr 2-3
• Strony: 369--380
• Opis fizyczny: Bibliogr. 12 poz., rys., tab.

Twórcy

autor

Kruszewski S.

• Department of Medical Physics, Ludwik Rydygier Medical University, ul. Jagiellonska 13, 85-067 Bydgoszcz, Poland
• Institute of Mathematics and Physics, Academy of Technology and Agriculture, ul. Sylwestra Kaliskiego 7, 85-796 Bydgoszcz, Poland

autor

Siuda R.

• Institute of Mathematics and Physics, Academy of Technology and Agriculture, ul. Sylwestra Kaliskiego 7, 85-796 Bydgoszcz, Poland

autor

Ziomkowska B.

• Department of Medical Physics, Ludwik Rydygier Medical University, ul. Jagiellonska 13, 85-067 Bydgoszcz, Poland
• Institute of Mathematics and Physics, Academy of Technology and Agriculture, ul. Sylwestra Kaliskiego 7, 85-796 Bydgoszcz, Poland

autor

Cyrankiewicz M.

• Institute of Mathematics and Physics, Academy of Technology and Agriculture, ul. Sylwestra Kaliskiego 7, 85-796 Bydgoszcz, Poland

Bibliografia

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