Camptothecins affinity to HSA and membranes determined by fluorescence anisotropy measurements

• Autorzy: Kruszewski S. , Burke T.G.
• Języki publikacji: EN

Abstrakty

EN

The application of fluorescence spectroscopy methods in determining the properties of camptothecins – promising anticancer agents – is described in this paper. The fluorescence anisotropy measurements provide useful information about the binding of camptothecins to human serum albumin (HSA) and to cell membranes, which is important for potential clinical applications of these agents, and permits the selection from among many camptothecin analogues those the ones exhibiting desirable biomedical properties.

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Optica Applicata
• Rocznik: 2002
• Tom: Vol. 32, nr 4
• Strony: 721--730
• Opis fizyczny: bibliogr. 11 poz.

Twórcy

autor

Kruszewski S.

autor

Burke T.G.

• Department of Medical Physics, The Ludwik Rydygier University of Medical Sciences, ul. Jagiellońska 13, 85-067 Bydgoszcz