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The aim of this work was preparation and characterization of o/w nano and microemulsions containing Crodamol PCŽ as the oil phase. An influence of surfactants system applied in formulations on the properties of the obtained emulsions has been studied. The emulsions were prepared by phase inversion composition method. The measurement of the internal phase droplet size and the study of rheological properties were done. The obtained results showed that the prepared transparent emulsion systems are nano and microemulsion formulation. Moreover, it was concluded that the microemulsions stability and the size of the internal phase droplets depended on the type and the concentration of emulsifier and on the ratio of water phase to oil. Rheological studies have confirmed that the obtained microemulsions showed pseudoplastic behaviour.
Czasopismo
Rocznik
Tom
Strony
68--73
Opis fizyczny
Bibliogr. 18 poz., tab., rys.
Twórcy
autor
autor
autor
- Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Warszawska St. 24, 31-155 Krakow, Poland, mjaworska@chemia.pk.edu.pl
Bibliografia
- 1. Somasundaran, P.,. Chakraborty, S, Deo, N. & Somasundran, T. (2006). Nanoencapsulation for Extraction and Release of Fragrance. Cosmetics&Toiletries. 12, 47-54.
- 2. Kothekar, S.C., Waghmare, J.T. & Momin, S.A. (2006). Rationalizing and Producing Nanoemulsions for Personal Care. Cosmetics&Toiletries. 7, 51-56.
- 3. Usón, N., Garcia, M.J. & Solans, C. (2004). Formation of water-in-oil (W/O) nano-emulsions in a water/mixed non-ionic surfactant/oil systems prepared by a low-energy emulsification method. Colloids and Surfaces A: Physicochem. Eng. Aspects. 250, 415-421. DOI: 10.1016/j.colsurfa.2004.03.039.
- 4. Sadurni, N., Solans, C., Azemar, N. & Garcia-Celma, M.J. (2005). Studies on the formation of O/W nano-emulsions, by low energy emulsification methods, suitable for pharmaceutical applications. European Journal of Pharmaceutical Sciences. 26, 438-445. DOI: 10.1016/j.ejps.2005.08.001.
- 5. Tadros, T., Izquierdo, P., Esquena, J. & Solans, C. (2004). Formation and stability of nano-emulsions. Advances in Colloidand Interface Science. 108-109, 303-318. DOI: 10.1016/j. cis.2003.10.023.
- 6. Bouchemal, K., Briancon, S., Perrier, E. & Fessi, H. (2004). Nano - emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. InternationalJournal of Pharmaceutics. 280, 241-251. DOI: 10.1016/j.1016/j. ijpharm.2004.05.016.
- 7. Porras, M., Solans, C., Gonzalez, C. & Gutierrez, J.M. (2008). Properties of water-in-oil (W/O) nano-emulsions prepared by a low-energy emulsification method. Colloids andSurfaces A: Physicochem. Eng. Aspects. 324, 181-188. DOI: 10.1016/j.colsurfa.2008.04.012.
- 8. Izquierdo, P., Feng, J., Esquena, J., Tadros, T.F., Dederen, J.C., Garcia, M.J., Azemar, N. & Solans, C. (2005). The influence of surfactant mixing ratio on nano-emulsion formation by the pit method. Journal of Colloid and Interface Science. 285, 388-394. DOI: 10.1016/j.jcis.2004.10.047.
- 9. Peng, L-C., Liu, C-H., Kwan, C-C. & Huang, K-F. (2010). Optimization of water-in-oil nanoemulsions by mixed surfactants. Colloids and Surfaces A: Physicochem. Eng. Aspects. 370, 136-142. DOI: 10.1016/j.colsurfa.2010.08.060.
- 10. Fernandez, P., Andre, V., Rieger, J. & Kühnle, A. (2004). Nano-emulsion formation by emulsion phase inversion. Colloidsand Surfaces. 251, 53-58. DOI: 10.1016/j.colsurfa.2004.09.029.
- 11. Yang, H.J., Cho, W.G. & Park, S.N. (2009). Stability of oil-in-water nano-emulsions prepared using the phase inversion composition method. Journal of Industrial and EngineeringChemistry. 15, 331-335. DOI: 10.1016/j.jiec.2009.01.001.
- 12. Patel, M.R., Patel, R.B., Parikh, J.R., Bhatt, K.K. & Solanki, A.B. (2010). Investigating the effect of vehicle on in vitro skin permeation of ketoconazole applied in O/W microemulsions. Acta Pharmaceutica Sciencia. 52, 65-77.
- 13. Shafiq-un-Nabi, S., Shakeel, F., Talegaonkar, S., Ali, J., Baboota, S., Ahuja, A., Khar, R.K. & Ali, M. (2007). Formulation Development and Optimization Using Nanoemulsion Technique: A Technical Note. AAPS Pharm. Sci. Tech. 8, E1-E6.
- 14. Caldero, G., Garcia-Celma, M.J. & Solans, C. (2011). Formation of polymeric nano-emulsions by a low-energy method and their use for nanoparticle preparation. Journal ofColloid and Interface Science. 353, 406-411. DOI: 10.1016/j. jcis.2010.09.073.
- 15. Kotyla, T., Kuo, F., Moolchandani, V., Wilson, T. & Nicolosi, R. (2008). Increased bioavailability of a transdermal application of a nano-sized emulsion preparation. InternationalJournal of Pharmaceutics. 347, 144-148. DOI: 10.1016/j. ijpharm.2007.06.045.
- 16. Chen, H.,. Chang, X, Weng, T., Zhao, X., Gao, Z., Yang, Y., Xu, H. & Yang, X. (2004). A study of microemulsion systems for transdermal delivery of triptolide. Journal of ControlledRelease. 98, 427-436. DOI: 10.1016/j.jconrel.2004.06.001.
- 17. Sole, I., Pey, C.M., Maestro, A., Gonzalez, C., Porras, M., Solans, C., Gutierrez, J.M. (2010). Nano-emulsions prepared by the phase inversion composition method: Preparation variables and scale. Journal of Colloid and Interface Science. 344, 417-423. DOI: 10.1016/j.jcis.2009.11.046.
- 18. Zieliński, R. (2000). Surfaktanty, towaroznawcze i ekologiczne aspekty ich stosowania, Wydawnictwo Akademii Ekonomicznej w Poznaniu. [in Polish].
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPS4-0005-0013