Geny BRCA1 i BRCA2. Struktura i funkcja, rola w naprawie DNA i regulacja transkrypcji

• Autorzy: Bartłomiejczyk T.
• Języki publikacji: PL

Słowa kluczowe

PL

gen BRCA1; gen BRCA2; naprawa DNA

• Wydawca: Polskie Towarzystwo Nukleoniczne
• Czasopismo: Postępy Techniki Jądrowej
• Rocznik: 2001
• Tom: Vol. 44, z. 4
• Strony: 57--61
• Opis fizyczny: Bibliogr. 19 poz., rys.

Twórcy

autor

Bartłomiejczyk T.

• Instytut Chemii i Techniki Jądrowej, Warszawa

Bibliografia

• [1] Miki Y., Swensen J., Shattuck-Eldens D., Futreal P.A., Harshaman K., Tavtigian S., Liu Q., Cochran C., Bennett L.M., Ding W. i in.: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71, 1994.
• [2] Wooster R., Bignell G., Lancaster J., Swift S., Seal S., Mangion J., Collins N., Gregory S., Gumbs C., Micklem G. i in.: Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789-791, 1995.
• [3] Wong A.K.C, Pero R., Ormonde P.A., Tavtigan S.V., Bartel P.L.: RAD51 interacts with the evolutionary conserved Brc motifs in the human breast cancer susceptibility gene brca2 J. Biol. Chem. 272, 31941-31944, 1997.
• [4] Vaughn J.P., Davis P.L., Jarboe M.D., Hoper G., Evans A.C, Wiseman R.W., Berchuck A., Iglehart J.D., Futreal P.A., Marks J.R.: BRCA1 expression is induced before DNA synthesis in both normal and tumour-derived breast cells. Cell Growth Diff. 7, 711-715, 1996.
• [5] Welcsh P.L., Owens K.N., King M.C: Insights into the functions of BRCA1 i BRCA2. Trends in Genetics. 16, 69-74, 2000.
• [6] Scully R., Anderson S.F., Chao D.M., Wei W., Ye L, Young R.A. Livingston D.M., Parvin J.D.: BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA 94, 5605-5610, 1997.
• [7] Bertwistle D., Ashworth A.: Functions of the BRCA1 and BRCA2 genes. Curr. Opin. Genet. Dev. 8, 14-20, 1998.
• [8] Thakur S., Zhang H.B., Peng Y.: Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol. Cell. Biol. 17, 444-452, 1997.
• [9] McAllister K.A., Haugen Strano A., Hagevik S., Brownlee H.A., Collins N.K., Futreal P.A., Bennett L.M., Wieseman R.W.: Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene. Cancer Res. 57, 3121-3125, 1997.
• [10] Kruszewski M.: Popromienne podwójnoniciowe pęknięcia DNA: zagrożenia i korzyści. Postępy Techniki Jądrowej 42, 48-53, 1999.
• [11] Scully R., Chen J., Ochs R.L., Keegan K., Hoekstra M., Feunteun J., Livingston D.M.: Dynamic changes of BRCA1 subnuclear localisation and phosphorylation state are initiated by DNA damage. Cell 90, 425-435, 1997.
• [12] Chen J., Silver DP., Walpita D., Cantor S.B., Gazdar A.F., Tomlinson G., Couch F.J., Weber B.L., Ashley T., Livingston D.M., Scully R.: Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2, 317-328, 1998.
• [13] Scully R., Chen J., Plug A., Xioa Y., Weaver D., Feunteun J., Ashley T., Livingston D.M.: Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275,1997.
• [14] Li S., Chen P.L., Subramanin T. i in.: Binding of CtIP to the BRCT repeats of BRAC1 involved in the transcription regulation of p21 is discruped upon DNA damage. J. Biol. Chem., 274, 11334-11338, 1999.
• [15] Anderson S.F., Schlegel B.P., Nakajima T., Wolpin E.S., Parvin J.D.: BRCA1 protein is linked to RNA polymerase II holoenzyme complex via RNA helicase A. Nat. Genet. 19, 254-256, 1998.
• [16] Wang Q., Zhang H., Kajino K., Greene M.I.: BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene 17, 1939-1948, 1998.
• [17] Milner J., Ponder B., Hughes-Davies L., Seltmann M., Kouzarides T.: Transcriptional activation functions in BRCA2. Nature 386, 772-773, 1997.
• [18] Nordling M., Karlsson P., Wahlstrom J., Engwall Y., Wallgren A., Martisson T.: A large deletion disrupts the exon 3 transcription activation domain of the BRCA2 gene in a breast/ovarian cancer family. Cancer Res. 58,1372-1375, 1998.
• [19] Callebaut I., Mornon J.P.: From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400, 25-30, 1997.