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Warianty tytułu
Synthesis and interaction with albumin of N,N-dimethylaminbenzyl derivative of thiosemicarbazone and its ruthenium(II) complex
Języki publikacji
Abstrakty
Z literatury wiadomo, że niektóre tiosemikarbazony wykazują działanie antynowotworowe jako inhibitory reduktazy rybonukleotydowej, a ich koordynacja do jonów Ru może prowadzić do wzmocnienia tej reaktywności. W artykule przedstawiono syntezę tiosemikarbazonu N,N-p-dimetyloaminobenzaldehydu oraz jego kompleksu z Ru(II). Zbadano oddziaływanie otrzymanych związków z albuminą przy użyciu metod spektrofluorymetrycznych. Wykazano, że po związaniu w kompleks ligand jest mniej reaktywny w stosunku do albuminy, co rokuje nadzieje na jego lepszą biodystrybucję.
Previous studies have shown that some thiosemicarbazones have antitumor activity as inhibitors of ribonucleotide reductase and their reactivity can be enhanced by coordination to Ru ion. The following paper describes the synthesis of N,N-p-dimethylaminbenzaldehyde thiosemicarbazone and its Ru(II) complex. In addition, the interaction of the obtained compounds with albumin was carried out using fluorescence spectroscopy. It has been shown that coordination of ligand to ruthenium decrease its reactivity towards albumin and therefore the better bioavailability is expected.
Czasopismo
Rocznik
Tom
Strony
91--98
Opis fizyczny
Bibliogr. 13 poz.
Twórcy
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-article-BPP2-0025-0094