Synthesis of (R) and (S)-2-[4-(4'-difluoromethylsulfonyl-2'-nitrophenylamino)phenoxy]propionic acid derivatives as new pesticides

• Autorzy: Ochal Z. , Gałązka J.
• Języki publikacji: EN

Abstrakty

EN

The synthesis of (R) and (S)-2-phenoxypropionie acid derivatives bearing difluoromethylsulfonyl-nitrophenyl group, such as: phcnoxypropionamides, phenoxypropionhydrazides, phenoxypro-pionhydrazones and phcnoxypropionsemicarbazides as a new compounds with potential pesticidal activity is reported. The title compounds were obtained starting from the proper phenol synthesized from difluoroniethyl-3-nitro-4-chlorophenyl sulfone and 4-aminophenole. Obtained phenol was transformed into optically active phenoxypropionic acid ethyl esters in reaction with (S)-(-)-tosy!oxy ethyl lactate and (R)-(+)-2-chloropropionic acid ethyl ester. They were hydrolyzed, and then obtained acids were converted into chlorides. Phenoxy acid chlorides were subjected to the reaction with amines. Phenoxypropionic acid ethyl esters are transformed in reaction with hydrazine hydrate into hydrazides, which were used to the reaction with aldehydes and isocyanates. Optical purity of the synthesized compounds were determined using HPLC equipped with chiral columns. Characteristic IR spectroscopic data and microelernentary analyses of the new products are reported.

Słowa kluczowe

EN

difluoromethylphenyl sulfone; 2-phenoxypropionic acid derivatives; enantiomer excess; pesticides

PL

sulfon; pochodna kwasu propionowego; nadmiar enancjomeryczny; pestycydy

• Wydawca: Centrum Materiałów Polimerowych i Węglowych PAN
• Czasopismo: Polish Journal of Applied Chemistry
• Rocznik: 2006
• Tom: Vol. 50, nr 1-2
• Strony: 13--27
• Opis fizyczny: Bibliogr. 8 poz.

Twórcy

autor

Ochal Z.

autor

Gałązka J.

• Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, Pl. 00-664 Warsaw, Poland,

Bibliografia

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