Preliminary optimization of direct amination of 1-(2,6-dimethylphenoxy)-2-propanol. synthesis of 1-(2,6-dimethylphenoxy)-2-aminopropane

• Autorzy: Leś A. , Kajl M. , Szelejewski W.
• Języki publikacji: EN

Abstrakty

EN

Preliminary steps were reported of optimization of catalytic amination of 1-(2,6-dimethylophenoxy)-2-propanol in our new synthesis of 1-(2,6-dimethylphenoxy)-2-aminopropane (mexiletine). In our search for optimal conditions a series of experiments were performed based on the concept of fractional factorial design. A detailed statistical analysis of reaction responses indicated necessary modifications of the synthesis. Elevated temperatures and the use of a more efficient catalyst were found necessary in order to use direct amination in industrial synthesis of pharmaceutically important amine from commercially available alcohol.

Słowa kluczowe

EN

mexiletine; direct amination of alcohols; optimization; fractional factorial design; response surface analysis

PL

meksyletyna; aminowanie alkoholi; optymalizacja; planowanie czynnikowe; powierzchnia odpowiedzi

• Wydawca: Centrum Materiałów Polimerowych i Węglowych PAN
• Czasopismo: Polish Journal of Applied Chemistry
• Rocznik: 2005
• Tom: Vol. 49, nr 3
• Strony: 195--203
• Opis fizyczny: Bibliogr. 15 poz., tabl. 3, rys. 1

Twórcy

autor

Leś A.

• Pharmaceutical Research Institute, 8 Rydygiera, 01-793 Warszawa, Poland
• Faculty of Chemistry, University of Warsaw, 1 Pasteura, 02-093 Warszawa, Poland

autor

Kajl M.

• Pharmaceutical Research Institute, 8 Rydygiera, 01-793 Warszawa, Poland

autor

Szelejewski W.

• Pharmaceutical Research Institute, 8 Rydygiera, 01-793 Warszawa, Poland

Bibliografia

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