Dehydration of exo-hydroxymethyl group in androstane derivative: optimization and scale-up

• Autorzy: Wojciechowska W. , Kutner A. , Leś A. , Szelejewski W.
• Języki publikacji: EN

Abstrakty

EN

Exploration of several process parameters (temperature, solvent composition, amount of concentrated HCl, scale-up factor) supported by an analysis of the reaction response surfaces fitted to the experimental data allowed to determine convenient and amenable for considerable scale-up route of dehydration of exo-hydroxymethyl group in androstane skeleton affording exemestane in high yield.

Słowa kluczowe

EN

exemestane; dehydration; optimization; scale-up

PL

exemestan; dehydratacja; optymalizacja

• Wydawca: Centrum Materiałów Polimerowych i Węglowych PAN
• Czasopismo: Polish Journal of Applied Chemistry
• Rocznik: 2004
• Tom: Vol. 48, nr 3-4
• Strony: 63--74
• Opis fizyczny: Bibliogr. 17 poz., rys. 2, tab. 3

Twórcy

autor

Wojciechowska W.

• Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warsaw, Poland

autor

Kutner A.

• Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warsaw, Poland

autor

Leś A.

• Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warsaw, Poland , Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland

autor

Szelejewski W.

• Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warsaw, Poland

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