Sensitivity analysis of deterministic signaling pathways models

• Autorzy: Puszyński K. , Lachor P. , Kardyńska M. , Śmieja J.
• Języki publikacji: EN

Abstrakty

EN

The paper is focused on application of sensitivity methods to analysis of signaling pathway models. Two basic methods are compared: local, based on standard sensitivity functions, and global, based on Sobol indices. Firstly, a general outline of modeling of signaling pathways by means of ordinary differential equations is briefly described. Afterwards, the methods of sensitivity analysis, known from literature, are introduced and illustrated with a simple example of a dynamical system of the second order. Subsequently, the analysis of the p53/Mdm2 regulatory module, which is a key element of any pathway involving p53 protein, is presented. The results of this analysis suggest that no single method should be chosen for investigation of any signaling pathway model but several of them should be applied to answer important questions about sources of heterogeneity in cells behavior, robustness of signaling pathways and possible molecular drug targets.

Słowa kluczowe

EN

signaling pathways; sensitivity analysis

• Wydawca: Polska Akademia Nauk, Wydział IV Nauk Technicznych
• Czasopismo: Bulletin of the Polish Academy of Sciences. Technical Sciences
• Rocznik: 2012
• Tom: Vol. 60, nr 3
• Strony: 471--479
• Opis fizyczny: Bibliogr. 25 poz., rys., tab.

Twórcy

autor

Puszyński K.

autor

Lachor P.

autor

Kardyńska M.

autor

Śmieja J.

• Institute of Automatic Control, Silesian University of Technology, 16 Akademicka St., 44-100 Gliwice, Poland

Bibliografia

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