Influence of 1,3,4-Thiadiazole Derivatives on the Biological Activity of the Selected Environmental Bacteria

• Autorzy: Rauckyte-Żak T. , Szejniuk B.

Warianty tytułu

PL

Wpływ pochodnych 1,3,4-tiadiazoli na aktywność wybranych bakterii środowiskowych

• Języki publikacji: EN

Abstrakty

EN

The paper presents the results of microbiological research carried out with the living microorganisms participation and in the domestic sewage and sludge from municipal sewage treatment plants environment. The influence of the selected heterocyclic compounds – the derivatives of 1,3,4-thiadiazole on susceptibility of aerobic Gram-positive and Gram-negative bacteria was investigated. For the research of biological activity the following environmental bacterial strains were selected: Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Proteus mirabilis, Enterococcus faecium, Salmonella senftenberg, and Salmonella typhimurium. For the group of the tested bacteria, 2-amino-1,3,4-thiadiazole turned out to be the most active chemical compound. It was found that evenly matched concentrations of this compound allow for the selective elimination of such microorganisms as: Salmonella senftenberg, Bacillus cereus, Staphylococcus aureus and Enterococcus faecium. In the case of Escherichia coli, the minimum inhibitory concentration (MIC) was detected at the level of 12.5 mg/cm3 (determined in relation to 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, bis(2-acetylamino-1,3,4-thiadiazole)-5,5’-disulfonamide), and for 2-amino-1,3,4-thiadiazole: 0.5 mg/cm3. Similar results were observed in case of Enterococcus faecium bacterium: MIC for 2-amino-1,3,4-thiadiazole was less than 0.25 mg/cm3, and MIC for bis(2-acetylamino- -1,3,4-thiadiazole)-5,5’-disulfonamide this level was equal to 25.0 mg/cm3.

PL

Przedstawiono wyniki badań mikrobiologicznych, prowadzonych z udziałem mikroorganizmów, występujących m.in. w środowisku biologicznym ścieków gospodarczo-bytowych oraz w osadach ściekowych z komunalnych oczyszczalni. Badano wpływ wybranych związków heterocyklicznych pochodnych 1,3,4-tiadiazolu na wrażliwość bakterii aerobowych Gram-dodatnich i Gram-ujemnych. Do badań aktywności biologicznej wytypowano szczepy bakterii środowiskowych: Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Proteus mirabilis, Enterococcus faecium, Salmonella senftenberg i Salmonella typhimurium. Dla badanej grupy bakterii najbardziej aktywnym związkiem chemicznym okazał się 2-amino-1,3,4-tiadiazol. Stwierdzono, że odpowiednio dobrane stężenia tego związku pozwalają na selektywną eliminację takich drobnoustrojów, jak: Salmonella senftenberg, Bacillus cereus, Staphylococcus aureus i Enterococcus faecium. W przypadku Escherichia coli najniższe stężenie hamujące wzrost bakterii (MIC) stwierdzono na poziomie 12,5 mg/cm3 (wyznaczone względem 2-acetyloamino-1,3,4-tiadiazolo-5-sulfonamidu i bis(2-acetyloamino-1,3,4-tiadiazolo)-5,5'-disulfonamidu), a dla 2-amino-1,3,4-tiadiazolu 0,5 mg/cm3. Podobne wyniki uzyskano w przypadku bakterii Enterococcus faecium z tym, że dla 2-amino-1,3,4-tiadiazolu MIC < 0,25 mg/cm3, a dla bis(2-acetylamino-1,3,4-tiadiazolo)-5,5'-disulfonamidu MIC = 25,0 mg/cm3.

Słowa kluczowe

EN

1,3,4-thiadiazole derivatives; microbiological research; sanitary status indicator

PL

pochodne 1,3,4-tiadiazolu; badania mikrobiologiczne; wskaźnik sanitarny środowiska

• Wydawca: Towarzystwo Chemii i Inżynierii Ekologicznej
• Czasopismo: Ecological Chemistry and Engineering. A
• Rocznik: 2011
• Tom: Vol. 18, nr 12
• Strony: 1691--1704
• Opis fizyczny: Bibliogr. 25 poz., tab., rys.

Twórcy

autor

Rauckyte-Żak T.

autor

Szejniuk B.

• Faculty of Chemical Technology and Engineering, University of Technology and Life Sciences, ul. Seminaryjna 3, 85–326 Bydgoszcz, Poland,

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