Drug release from hydrogel matrices

• Autorzy: Zarzycki R. , Modrzejewska Z. , Nawrotek K.

Warianty tytułu

PL

Uwalnianie leków z hydrożeli

• Języki publikacji: EN

Abstrakty

EN

Description of the kinetics of drug release from hydrogels is a domain of steadily increasing academic and industrial importance. The aim of this paper is to review mathematical approaches to drug release from hydrogel matrix devices. In the first section the parameters of hydrogel structure are described. Than the phenomena that influencing resulting drug release are discussed. Finally, mechanisms of physical release and release with chemical reaction are studied. In this section mathematical expression that predicting drug release profiles are described.

PL

Zarówno z naukowego, jak i praktycznego punktu widzenia bardzo ważny jest opis kinetyki uwalniania leków z hydrożeli. Celem tego artykułu jest przegląd opisanych w literaturze modeli matematycznych uwalniania leków z matryc hydrożelowych. W pierwszej części omówiono parametry opisujące strukturę hydrożelu. Następnie opisano zjawiska wpływające na mechanizm uwalniania leków. W ostatniej części przeglądu literatury zostały przedstawione mechanizmy uwalniania. W tej części zebrano wyrażenia matematyczne stosowane do opisu profili uwalniania leków.

Słowa kluczowe

EN

hydrogel; mathematical modelling; controlled release; drug delivery; diffusion; swelling; erosion

PL

hydrożel; modelowanie matematyczne; kontrolowane uwalnianie; podawanie leków; dyfuzja; pęcznienie; erozja

• Wydawca: Towarzystwo Chemii i Inżynierii Ekologicznej
• Czasopismo: Ecological Chemistry and Engineering. S
• Rocznik: 2010
• Tom: Vol. 17, nr 2
• Strony: 117--136
• Opis fizyczny: Bibliogr. 27 poz., rys., tab.

Twórcy

autor

Zarzycki R.

autor

Modrzejewska Z.

autor

Nawrotek K.

• Wydział Inżynierii Procesowej i Ochrony Środowiska, Politechnika Łódzka,

Bibliografia

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