Nanoscale computational analysis for an idealized bio-molecular motor

• Autorzy: Pidaparti R.M. , Longest P.W. , Hsu A.T. , Akay H.U.
• Języki publikacji: EN

Abstrakty

EN

Molecular motors are nature's nanomachines and are the essential agents of movement that are an integral part of many living organisms. The supramolecular machine, called the nuclear pore complex (NPC), controls the transport of all cellular material between the cytoplasm and the nucleus that occurs naturally in all biological cells. In the presence of appropriate chemical stimuli, the NPC opens or closes, like a gating mechanism, and permits the flow of material into and out of the nucleus. As a first step in understanding the design characteristics of the NPC, nanoscale studies were conducted to understand the transport characteristics of an idealized NPC model using CFD analysis, discrete element transport and coupled fluid-solid analysis. Results of pressure and velocity profi1es obtained from the model s indicate that the fluid density, flexibility of walls and the geometry of the flow passage are important in the design of NPC based nano- and micro-motors.

Słowa kluczowe

EN

molecular motors; atomic force microscopy (AFM); nuclear pore complex; design; simulation

• Wydawca: Polska Akademia Nauk, Wydział IV Nauk Technicznych
• Czasopismo: Bulletin of the Polish Academy of Sciences. Technical Sciences
• Rocznik: 2005
• Tom: Vol. 53, nr 4
• Strony: 405--412
• Opis fizyczny: Bibliogr. 28 poz., 12 rys.

Twórcy

autor

Pidaparti R.M.

autor

Longest P.W.

autor

Hsu A.T.

autor

Akay H.U.

• Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, V A 23284, USA,

Bibliografia

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